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【结 构 式】 
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【分子编号】31697 【品名】1-[4-(benzyloxy)phenyl]-2-[(3,4-dimethoxyphenethyl)imino]-1-ethanone 【CA登记号】 |
【 分 子 式 】C25H25NO4 【 分 子 量 】403.47784 【元素组成】C 74.42% H 6.25% N 3.47% O 15.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIII)The oxidation of 4-benzyloxyphenacyl chloride (XV) with KI and DMSO gives 4-benzyloxy-alpha-oxophenylacetaldehyde (XVII), which is condensed with the amine (IV) to afford the corresponding Schiff base (XVIII). Finally, this compound is reduced with NaBH4 yielding the protected product (VI), already obtained.
| 【1】 Ikezaki, M.; Umino, N.; Iwakuma, T.; Process for preparation of benzyl alcohol derivatives. JP 52051334 . |
| 【2】 Ikezaki, M.; Umino, N.; Iwakuma, T.; Process for preparation of benzyl alcohol derivatives. JP 52051335 . |
| 【3】 Blancafort, P.; Castaner, J.; Serradell, M.N.; TA-064. Drugs Fut 1982, 7, 6, 407. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 10098 | 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine | 120-20-7 | C10H15NO2 | 详情 | 详情 |
| (VI) | 31687 | (1R)-1-[4-(benzyloxy)phenyl]-2-[(3,4-dimethoxyphenethyl)amino]-1-ethanol | C25H29NO4 | 详情 | 详情 | |
| (XV) | 31689 | 4-Benzyloxyphenacyl chloride; 1-[4-(Benzyloxy)phenyl]-2-chloro-1-ethanone | 39188-62-0 | C15H13ClO2 | 详情 | 详情 |
| (XVII) | 31696 | 2-[4-(benzyloxy)phenyl]-2-oxoacetaldehyde; 4-benzyloxy-alpha-oxophenylacetaldehyde | C15H12O3 | 详情 | 详情 | |
| (XVIII) | 31697 | 1-[4-(benzyloxy)phenyl]-2-[(3,4-dimethoxyphenethyl)imino]-1-ethanone | C25H25NO4 | 详情 | 详情 |
Extended Information