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【结 构 式】 
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【分子编号】31618 【品名】(2R)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N(1)-[(1S)-2-cyclohexyl-1-[(4R,5S)-5-isobutyl-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl]-N(4)-(cyclohexylmethyl)-N(4)-(2-[methyl[2-(2-pyridinyl)ethyl]amino]-2-oxoethyl)butanediamide 【CA登记号】 |
【 分 子 式 】C42H66N6O5S 【 分 子 量 】767.08948 【元素组成】C 65.76% H 8.67% N 10.96% O 10.43% S 4.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVII)The thiazole ring formation by cyclization of (XV) with thiourea (XVI) gives intermediate (XVII), which is finally deprotected with methanesulfonic acid in dichloromethane.
| 【1】 Beaulieu, P.L.; et al.; Practical synthesis of BILA 2157 BS, a potent and orally active renin inhibitor: Use of an enzayme-catalyzed hydrolysis for the preparation of homochiral succinic acid derivatives. J Org Chem 1999, 64, 18, 6622. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XV) | 31617 | (2R)-2-(3-bromo-2-oxopropyl)-N(1)-[(1S)-2-cyclohexyl-1-[(4R,5S)-5-isobutyl-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl]-N(4)-(cyclohexylmethyl)-N(4)-(2-[methyl[2-(2-pyridinyl)ethyl]amino]-2-oxoethyl)butanediamide | C41H65BrN4O6 | 详情 | 详情 | |
| (XVI) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (XVII) | 31618 | (2R)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N(1)-[(1S)-2-cyclohexyl-1-[(4R,5S)-5-isobutyl-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl]-N(4)-(cyclohexylmethyl)-N(4)-(2-[methyl[2-(2-pyridinyl)ethyl]amino]-2-oxoethyl)butanediamide | C42H66N6O5S | 详情 | 详情 |
Extended Information