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【结 构 式】 
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【分子编号】31429 【品名】4,7-dimethoxy-2-(methoxymethyl)-1-methyl-1H-benzimidazole; (4,7-dimethoxy-1-methyl-1H-benzimidazol-2-yl)methyl methyl ether 【CA登记号】 |
【 分 子 式 】C12H16N2O3 【 分 子 量 】236.27072 【元素组成】C 61% H 6.83% N 11.86% O 20.31% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Methylation of (hydroxymethyl)benzimidazole (I) at the amino and hydroxyl groups with MeI and NaH provided (II). Subsequent formylation of (II) employing dichloromethyl methyl ether and SnCl4 gave aldehyde (III), which was condensed with the phenylenediamine derivative (IV) in nitrobenzene to produce the bis(benzimidazole) (V). Finally, cleavage of the methyl ethers of (V) with BBr3 in toluene yielded the title compound.
| 【1】 Soderlind, K.-J.; et al.; Bis-benzimidazole anticancer agents: Targeting human tumour helicases. Anti-Cancer Drug Des 1999, 14, 1, 19. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31428 | (4,7-dimethoxy-1H-benzimidazol-2-yl)methanol | C10H12N2O3 | 详情 | 详情 | |
| (II) | 31429 | 4,7-dimethoxy-2-(methoxymethyl)-1-methyl-1H-benzimidazole; (4,7-dimethoxy-1-methyl-1H-benzimidazol-2-yl)methyl methyl ether | C12H16N2O3 | 详情 | 详情 | |
| (III) | 31431 | 4,7-dimethoxy-2-(methoxymethyl)-1-methyl-1H-benzimidazole-5-carbaldehyde | C13H16N2O4 | 详情 | 详情 | |
| (IV) | 31430 | 2-amino-4-(4-methyl-1-piperazinyl)phenylamine; 4-(4-methyl-1-piperazinyl)-1,2-benzenediamine | 54998-08-2 | C11H18N4 | 详情 | 详情 |
| (V) | 31432 | 4,7-Dimethoxy-2-(methoxymethyl)-1-methyl-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidaole | C24H30N6O3 | 详情 | 详情 |
Extended Information