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【结 构 式】

【分子编号】31407

【品名】3-azetidinyl 4,5-dihydro-1,3-thiazol-2-yl sulfide; 2-(3-azetidinylsulfanyl)-4,5-dihydro-1,3-thiazole

【CA登记号】

【 分 子 式 】C6H10N2S2

【 分 子 量 】174.29088

【元素组成】C 41.35% H 5.78% N 16.07% S 36.8%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(XV)

A further procedure consisted in the opening of 1-azabicyclobutane (III) with 2-mercaptothiazoline (XIV) to give (XV). Subsequent rearrangement of (XV) in the presence of methanesulfonic acid produced thiazolinyl azetidine (XI).

1 Abe, T.; Isoda, T.; Sato, C.; Mihira, A.; Tamai, S.; Kumagai, T. (Lederle (Japan), Ltd.); 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivs.. EP 0632039; EP 0717042; JP 1996053453; US 5534510; US 5659043; US 5783703 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 31396 1-azabicyclo[1.1.0]butane C3H5N 详情 详情
(XI) 31404 1-(4,5-dihydro-1,3-thiazol-2-yl)-3-azetidinylhydrosulfide; 1-(4,5-dihydro-1,3-thiazol-2-yl)-3-azetidinethiol 179337-57-6 C6H10N2S2 详情 详情
(XIV) 28895 4,5-dihydro-1,3-thiazol-2-ylhydrosulfide 96-53-7 C3H5NS2 详情 详情
(XV) 31407 3-azetidinyl 4,5-dihydro-1,3-thiazol-2-yl sulfide; 2-(3-azetidinylsulfanyl)-4,5-dihydro-1,3-thiazole C6H10N2S2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(XV)

A further procedure consisted in the opening of 1-azabicyclobutane (III) with 2-mercaptothiazoline (XIV) to give (XV). Subsequent rearrangement of (XV) in the presence of methanesulfonic acid produced thiazolinyl azetidine (XI).

1 Abe, T.; Isoda, T.; Sato, C.; Mihira, A.; Tamai, S.; Kumagai, T. (Lederle (Japan), Ltd.); 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivs.. EP 0632039; EP 0717042; JP 1996053453; US 5534510; US 5659043; US 5783703 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 31396 1-azabicyclo[1.1.0]butane C3H5N 详情 详情
(XI) 31404 1-(4,5-dihydro-1,3-thiazol-2-yl)-3-azetidinylhydrosulfide; 1-(4,5-dihydro-1,3-thiazol-2-yl)-3-azetidinethiol 179337-57-6 C6H10N2S2 详情 详情
(XIV) 28895 4,5-dihydro-1,3-thiazol-2-ylhydrosulfide 96-53-7 C3H5NS2 详情 详情
(XV) 31407 3-azetidinyl 4,5-dihydro-1,3-thiazol-2-yl sulfide; 2-(3-azetidinylsulfanyl)-4,5-dihydro-1,3-thiazole C6H10N2S2 详情 详情
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