(2S,5R,8S,11S,14R,17S,20S,23S)-23-amino-11-(4-aminobutyl)-8-(tert-butyl)-24-(4-chlorophenyl)-14-(1H-indol-3-ylmethyl)-2-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-17-(3-pyridinylmethyl)-5,20-bis(sulfanylmethyl)-3,6,9,12,15,18,21-heptaazatetracos -Drug Synthesis Database

【结构式】

【分子编号】31383

【品名】(2S,5R,8S,11S,14R,17S,20S,23S)-23-amino-11-(4-aminobutyl)-8-(tert-butyl)-24-(4-chlorophenyl)-14-(1H-indol-3-ylmethyl)-2-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-17-(3-pyridinylmethyl)-5,20-bis(sulfanylmethyl)-3,6,9,12,15,18,21-heptaazatetracos

【CA登记号】

【分子式】C₅₉H₇₃ClN₁₂O₈S₂

【分子量】1177.8894

【元素组成】C 60.16% H 6.25% Cl 3.01% N 14.27% O 10.87% S 5.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIX)

Cleavage of the peptide (XVIII) from the resin support with simultaneous side-chain deprotection using anhydrous HF containing the scavengers anisole and dithiothreitol produced the peptide amide (XIX). This was finally cyclized to the title disulfide employing iodine in AcOH.

参考文献中间体

合成目标

【1】 Taylor, J.E.; Hocart, S.J.; Murphy, W.A.; Coy, D.H.; Jian, R.; Highly potent cyclic disulfide antagonists of somatostatin. J Med Chem 1999, 42, 11, 1863.
【2】 Murphy, W.; Coy, D.H.; Morgan, B. (Biomeasure Inc.; Tulane Educational Fund); Somatostatin antagonists. WO 9824807 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XVIII)	31380	S-[(2S,5S,8R,11S,14S,17R)-17-([[(1S)-2-amino-1-(2-naphthylmethyl)-2-oxoethyl]amino]carbonyl)-2-[[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)propanoyl]amino]-14-(tert-butyl)-11-[4-([[(2-chlorobenzyl)oxy]carbonyl]amino)butyl]-8-(1H-indol-3-		C₉₀H₁₀₂Cl₂N₁₂O₁₆S₂	详情	详情
(XIX)	31383	(2S,5R,8S,11S,14R,17S,20S,23S)-23-amino-11-(4-aminobutyl)-8-(tert-butyl)-24-(4-chlorophenyl)-14-(1H-indol-3-ylmethyl)-2-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-17-(3-pyridinylmethyl)-5,20-bis(sulfanylmethyl)-3,6,9,12,15,18,21-heptaazatetracos		C₅₉H₇₃ClN₁₂O₈S₂	详情	详情

Extended Information