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【结 构 式】 
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【分子编号】31335 【品名】3-chlorophenethylamine; 2-(3-chlorophenyl)-1-ethanamine 【CA登记号】13078-79-0 |
【 分 子 式 】C8H10ClN 【 分 子 量 】155.62684 【元素组成】C 61.74% H 6.48% Cl 22.78% N 9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)2-Amino-5-bromopyridine (I) was condensed with 1,1-thiocarbonyldiimidazole (II) in acetonitrile to furnish the precursor thiocarbonyl derivative (III). Further reaction of (III) with 3-chlorophenethylamine (IV) in DMF at 100 C gave the target thiourea.
| 【1】 Vig, R.; Mao, C.; Venkatachalam, T.K.; Tuel-Ahlgren, L.; Sudbeck, E.A.; Uckun, F.M.; Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. Bioorg Med Chem 1998, 6, 10, 1789. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12123 | 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine | 1072-97-5 | C5H5BrN2 | 详情 | 详情 |
| (II) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
| (III) | 26465 | methyl (2S,3R)-3-cyclopropyl-2,3-dihydroxypropanoate | C7H12O4 | 详情 | 详情 | |
| (IV) | 31335 | 3-chlorophenethylamine; 2-(3-chlorophenyl)-1-ethanamine | 13078-79-0 | C8H10ClN | 详情 | 详情 |
Extended Information