2-fluorophenethylamine; 2-(2-fluorophenyl)-1-ethanamine -Drug Synthesis Database

【结构式】

【分子编号】31333

【品名】2-fluorophenethylamine; 2-(2-fluorophenyl)-1-ethanamine

【CA登记号】

【分子式】C₈H₁₀FN

【分子量】139.1725432

【元素组成】C 69.04% H 7.24% F 13.65% N 10.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

2-Amino-5-bromopyridine (I) was condensed with 1,1-thiocarbonyldiimidazole (II) in acetonitrile to furnish the precursor thiocarbonyl derivative (III). Further reaction of (III) with 2-fluorophenethylamine (IV) in DMF at 100 C gave the target thiourea.

参考文献中间体

合成目标

【1】 Vig, R.; Mao, C.; Venkatachalam, T.K.; Tuel-Ahlgren, L.; Sudbeck, E.A.; Uckun, F.M.; Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. Bioorg Med Chem 1998, 6, 10, 1789.
【2】 Uckun, F.M. (Parker Hughes Institute); NNI for treatment of multi-drug resistant HIV. WO 0056736 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12123	5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine	1072-97-5	C₅H₅BrN₂	详情	详情
(II)	11990	Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole	6160-65-2	C₇H₆N₄S	详情	详情
(III)	26465	methyl (2S,3R)-3-cyclopropyl-2,3-dihydroxypropanoate		C₇H₁₂O₄	详情	详情
(IV)	31333	2-fluorophenethylamine; 2-(2-fluorophenyl)-1-ethanamine		C₈H₁₀FN	详情	详情

Extended Information