【结 构 式】 |
【分子编号】31280 【品名】3-[2-[((1S,2R,3S,4R)-3-[4-[(pentylamino)carbonyl]-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-yl)methyl]phenyl]propionic acid 【CA登记号】 |
【 分 子 式 】C25H32N2O5 【 分 子 量 】440.53956 【元素组成】C 68.16% H 7.32% N 6.36% O 18.16% |
合成路线1
该中间体在本合成路线中的序号:(XI)The interphenylene side chain was introduced by deprotonation of (I) with ethylmagnesium bromide (0.95 eq.) followed by treatment with excess aryl Grignard (II) to afford crystalline diol (III). The extraneous benzylic hydroxyl group in (III) was removed by reduction with hydrogen in the presence of Pearlman's catalyst to give alcohol (IV). Transformation of the alpha-side chain silyloxy carbinol to a carboxy methyl ester was accomplished by initial protection of the omega-side chain alcohol as the acetate (Ac2O/pyr) followed by oxidation under Jones conditions and then exposure of the resulting crude acetate-acid to methanolic hydrogen chloride to afford crystalline alcohol-ester (V). Oxidation of (V) under Jones conditions furnished acid-ester (VI). The oxazole side chain was introduced into (VI) via serine-derived amino alcohol (VII). Standard coupling of acid (VI) with (VII) mediated by water-soluble carbodiimide (EDAC) gave amide (VIII). Acyclic side chain intermediate (VIII) was converted into oxazole (X) in three steps by mesylation followed by treatment with triethylamine to furnish cyclized oxazoline (IX). Dehydrogenation of (IX) employing a novel oxidative protocol involving treatment with a mixture of copper (II) bromide and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in chloroform/ethyl acetate solvent yielded oxazole (X). Saponification of (X) followed by acidification afforded (XI) (BMS-180291) as a white solid which could be purified by recrystallization from acetonitrile. The water-soluble sodium salt was available as a precipitate from (XI) by treatment with sodium methoxide/methanol in acetone.
【1】 Han, W.-C.; Kronenthal, D.R.; Kissick, T.P.; Spergel, S.H.; Mueller, R.H.; Singh, J.; Barrish, J.C.; Cupric bromide mediated oxidation of 4-carboxyoxazolines to the corresponding oxazoles. J Org Chem 1993, 58, 4494-96. |
【2】 Misra, R.N.; White, R.E.; Ogletree, M.L.; Ifetroban Sodium < USAN >. Drugs Fut 1994, 19, 2, 107. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 14865 | (1S,2R,3S,6R,7R)-4,10-dioxatricyclo[5.2.1.0(2,6)]decan-3-ol | C8H12O3 | 详情 | 详情 | |
(II) | 14866 | bromo[2-(3-[[(3,3-dimethylbutyl)(dimethyl)silyl]oxy]propyl)phenyl]magnesium | C17H29BrMgOSi | 详情 | 详情 | |
(III) | 14867 | [2-(3-[[(3,3-dimethylbutyl)(dimethyl)silyl]oxy]propyl)phenyl][(1S,2S,3R,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-yl]methanol | C25H42O4Si | 详情 | 详情 | |
(IV) | 31279 | [(1R,2R,3R,4S)-3-[2-(3-[[(3,3-dimethylbutyl)(dimethyl)silyl]oxy]propyl)benzyl]-7-oxabicyclo[2.2.1]hept-2-yl]methanol | C25H42O3Si | 详情 | 详情 | |
(V) | 14869 | methyl 3-(2-[[(1S,2R,3R,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-yl]methyl]phenyl)propanoate | C18H24O4 | 详情 | 详情 | |
(VI) | 14870 | (1R,2S,3R,4S)-3-[2-(3-methoxy-3-oxopropyl)benzyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid | C18H22O5 | 详情 | 详情 | |
(VII) | 14871 | (2S)-2-amino-3-hydroxy-N-pentylpropanamide | C8H18N2O2 | 详情 | 详情 | |
(VIII) | 14872 | methyl 3-(2-[[(1S,2R,3S,4R)-3-([[(1S)-1-(hydroxymethyl)-2-oxo-2-(pentylamino)ethyl]amino]carbonyl)-7-oxabicyclo[2.2.1]hept-2-yl]methyl]phenyl)propanoate | C26H38N2O6 | 详情 | 详情 | |
(IX) | 14873 | methyl 3-[2-[((1S,2R,3S,4R)-3-[(4S)-4-[(pentylamino)carbonyl]-4,5-dihydro-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-yl)methyl]phenyl]propanoate | C26H36N2O5 | 详情 | 详情 | |
(X) | 31281 | methyl 3-[2-[((1S,2R,3S,4R)-3-[4-[(pentylamino)carbonyl]-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-yl)methyl]phenyl]propanoate | C26H34N2O5 | 详情 | 详情 | |
(XI) | 31280 | 3-[2-[((1S,2R,3S,4R)-3-[4-[(pentylamino)carbonyl]-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-yl)methyl]phenyl]propionic acid | C25H32N2O5 | 详情 | 详情 |