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【结 构 式】 
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【分子编号】31174 【品名】methyl 2-amino-2-methylpropanoate 【CA登记号】 |
【 分 子 式 】C5H11NO2 【 分 子 量 】117.14788 【元素组成】C 51.26% H 9.46% N 11.96% O 27.31% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The esterification of 2-aminoisobutyric acid (I) with methanol - HCl gives the corresponding methyl ester (II), which is formylated with formic acid - acetic anhydride or methyl formate yielding the formamide (III). Dehydration of (III) with diphosgene (DPG) or POCl3 in pyridine affords methyl 2-isocyanoisobutyrate (CPI) (IV). Finally, this compound or its ZnBr2 complex [Zn(CPI)2Br2] is treated with 99mTcO4 and sodium dithionite or SnCl2 respectively, in ethanol-water solution. The radiochemical purity was >95%.
| 【1】 Jones, A.G.; Davison, A.; Kronauge, J.; Abrams, M.J. (Harvard College; Massachusetts Institute of Technology); Carboxy, carboalkoxy and carbamile substd. isonitrile radionuclide complexes. EP 0213945 . |
| 【2】 Holman, B.L.; Sporn, V.; Jones, A.G.; et al.; Myocardial imaging with Tc-99m CPI: Initial experience in human. J Nucl Med 1987, 28, 13-18. |
| 【3】 Liu, X.-J.; Wang, X.-B.; Lahiri, A.; Prous, J.; Castaner, J.; [99m]-Tc-CPI. Drugs Fut 1990, 15, 9, 883. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31173 | 2-methylalanine；2-Aminoisobutyric acid;2-Amino-2-methylpropionic acid;alpha-Aminoisobutyric acid | 62-57-7 | C4H9NO2 | 详情 | 详情 |
| (II) | 31174 | methyl 2-amino-2-methylpropanoate | C5H11NO2 | 详情 | 详情 | |
| (III) | 31175 | methyl 2-(formylamino)-2-methylpropanoate | C6H11NO3 | 详情 | 详情 | |
| (IV) | 31176 | methyl 2-isocyano-2-methylpropanoate | C6H9NO2 | 详情 | 详情 |
Extended Information