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【结 构 式】 
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【分子编号】31114 【品名】(E)-3-methyl-6-oxo-2-hexenyl acetate 【CA登记号】 |
【 分 子 式 】C9H14O3 【 分 子 量 】170.20836 【元素组成】C 63.51% H 8.29% O 28.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)The condensation of homogeranyl iodide (III) with diethyl ethoxycarbony-methylphosphonate (IV) by means of NaH in diethoxyethane gives the phosphorane (V), which by a Wittig condensation with 4-methyl-6-acetoxy-4-hexenal (VI) by means of NaH yields 7-(ethoxycarbonyl)-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol acetate (VII). Finally, this compound is reduced and hydrolyzed by treatment with LiAlH4.
| 【1】 Mishima, H.; Ogiso, A.; Kobayashi, S.; Polyprenyl derivatives. CH 629471; DE 2652256; FR 2332009; GB 1533377; JP 52062213; US 4059641 . |
| 【2】 Castaner, J.; Serradell, M.N.; Blancafort, P.; Plaunotol. Drugs Fut 1983, 8, 11, 930. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 31112 | (6E)-9-iodo-2,6-dimethyl-2,6-nonadiene | C11H19I | 详情 | 详情 | |
| (IV) | 10019 | Ethyl 2-(diethoxyphosphoryl)acetate; Triethyl phosphonoacetate | 867-13-0 | C8H17O5P | 详情 | 详情 |
| (V) | 31113 | ethyl (5E)-2-(diethoxyphosphoryl)-6,10-dimethyl-5,9-undecadienoate | C19H35O5P | 详情 | 详情 | |
| (VI) | 31114 | (E)-3-methyl-6-oxo-2-hexenyl acetate | C9H14O3 | 详情 | 详情 | |
| (VII) | 31115 | ethyl (5E)-2-[(Z,4E)-6-(acetoxy)-4-methyl-4-hexenylidene]-6,10-dimethyl-5,9-undecadienoate | C24H38O4 | 详情 | 详情 |
Extended Information