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【结 构 式】 
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【分子编号】31111 【品名】(E)-4-methyl-7-(tetrahydro-2H-pyran-2-yloxy)-4-heptenal 【CA登记号】 |
【 分 子 式 】C13H22O3 【 分 子 量 】226.31588 【元素组成】C 68.99% H 9.8% O 21.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)By a Wittig condensation of 5,9-dimethyl-4,8-decadien-1-yltriphenylphosphonium iodide (I) with 4-methyl-6-tetrahydropyranyloxy-4-hexenal (II) using butyllithium as condensing agent in THF, followed by reaction with paraformaldehyde and sec-butyl lithiurn in the same solvent.
| 【1】 Ogiso, A.; et al.; Isolation and structure of antipeptic ulcer diterpene from Thai medicinal plant. Chem Pharm Bull 1978, 26, 10, 3117-23. |
| 【2】 Mishima, H.; Ogiso, A.; Kobayashi, S. (Sankyo Co., Ltd.); Polyprenyl derivatives. DE 2652256; FR 2332009; GB 1533377; JP 52062213; US 4059641 . |
| 【3】 Castaner, J.; Serradell, M.N.; Blancafort, P.; Plaunotol. Drugs Fut 1983, 8, 11, 930. |
Extended Information