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【结 构 式】 
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【分子编号】30826 【品名】9H-fluoren-9-ylmethyl (1S)-1-([[(1S)-2-amino-1-benzyl-2-oxoethyl]amino]carbonyl)-4-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]butylcarbamate 【CA登记号】 |
【 分 子 式 】C44H54N6O7S 【 分 子 量 】811.015 【元素组成】C 65.16% H 6.71% N 10.36% O 13.81% S 3.95% |
合成路线1
该中间体在本合成路线中的序号：(V)The compound was prepared via solid-phase synthesis using Rink-amide resin (I). After initial Fmoc-deprotection of (I) with piperidine in DMF, Fmoc-L-phenylalanine (II) was coupled to the resin by means of N,N'-diisopropyl carbodiimide (DIC) and hydroxybenzotriazole (HOBt) in DMF, yielding the phenylalanine-linked resin (III). Subsequent Fmoc-deprotection and coupling cycles with protected arginine (IV) and cyclohexylalanine (VI) produced the peptide resins (V) and (VII), respectively. Further deprotection of (VII) with piperidine, followed by coupling with 5-bromonicotinic acid (VIII) gave the corresponding amide (IX). Cleavage of the final peptide amide from the resin (IX) was then accomplished by treatment trifluoroacetic acid and anisole.
| 【1】 Addo, M.F.; Hawkins, M.J.; Maryanoff, B.E.; Oksenberg, D.; McComsey, D.F.; Andrade-Gordon, P.; Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1). Bioorg Med Chem Lett 1999, 9, 10, 1423. |
| 【2】 Hawkins, M.J.; Maryanoff, B.E.; McComsey, D.F. (Ortho-McNeil Pharmaceutical, Inc.); Substd. heterocyclic acyl-tripeptides useful as thrombin receptor modulators. WO 0035942 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28722 | 9H-fluoren-9-ylmethyl carbamate | 84418-43-9 | C15H13NO2 | 详情 | 详情 |
| (II) | 19030 | (2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-phenylpropionic acid; N-((9H-fluoren-9-ylmethoxy)carbonyl)-phenylalanine | 35661-40-6 | C24H21NO4 | 详情 | 详情 |
| (III) | 19031 | 9H-fluoren-9-ylmethyl (1S)-2-amino-1-benzyl-2-oxoethylcarbamate | C24H22N2O3 | 详情 | 详情 | |
| (IV) | 30825 | (2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]pentanoic acid | C35H44N4O7S | 详情 | 详情 | |
| (V) | 30826 | 9H-fluoren-9-ylmethyl (1S)-1-([[(1S)-2-amino-1-benzyl-2-oxoethyl]amino]carbonyl)-4-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]butylcarbamate | C44H54N6O7S | 详情 | 详情 | |
| (VI) | 30827 | (2S)-3-cyclohexyl-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]propionic acid | C24H27NO4 | 详情 | 详情 | |
| (VII) | 30828 | 9H-fluoren-9-ylmethyl (1S)-2-([(1S)-1-([[(1S)-2-amino-1-benzyl-2-oxoethyl]amino]carbonyl)-4-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]butyl]amino)-1-(cyclohexylmethyl)-2-oxoethylcarbamate | C53H69N7O8S | 详情 | 详情 | |
| (VIII) | 17913 | 5-Bromonicotinic acid | 20826-04-4 | C6H4BrNO2 | 详情 | 详情 |
| (IX) | 30829 | N-[(1S)-2-([(1S)-1-([[(1S)-2-amino-1-benzyl-2-oxoethyl]amino]carbonyl)-4-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]butyl]amino)-1-(cyclohexylmethyl)-2-oxoethyl]-5-bromonicotinamide | C44H61BrN8O7S | 详情 | 详情 |