• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】30780

【品名】methyl (2S)-1-(2-methoxy-2-oxoacetyl)-2-pyrrolidinecarboxylate

【CA登记号】

【 分 子 式 】C9H13NO5

【 分 子 量 】215.20596

【元素组成】C 50.23% H 6.09% N 6.51% O 37.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Acylation of L-proline methyl ester (I) with methoxalyl chloride (II) afforded oxamate (III), which was condensed with 1,1-dimethylpropyl magnesium chloride to produce ketoamide (IV). Hydrolysis of the methyl ester of (IV) with LiOH gave carboxylic acid (V). This was finally coupled with 3,3-diphenylpropyl mercaptan (VI) using DCC and dimethylaminopyridine to give the title thioether.

1 Limburg, D.C.; et al.; Synthesis of thioester FKBP12 ligands and evaluation of their in vitro and in vivo nerve regenerative effects. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 237.
2 Hamilton, G.S.; Li, J.-H. (Guilford Pharmaceuticals Inc.); Heterocyclic thioesters and ketones. EP 0934263; US 5786378; US 5990131; WO 9813343 .
3 Hamilton, G.S.; Steiner, J.P. (Guilford Pharmaceuticals Inc.); Hair growth compsns. and uses. WO 9855090 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 29552 methyl (2S)-2-pyrrolidinecarboxylate 2133-40-6 C6H11NO2 详情 详情
(II) 26971 2-methoxy-2-oxoacetyl chloride 5781-53-3 C3H3ClO3 详情 详情
(III) 30780 methyl (2S)-1-(2-methoxy-2-oxoacetyl)-2-pyrrolidinecarboxylate C9H13NO5 详情 详情
(IV) 30781 methyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-pyrrolidinecarboxylate C13H21NO4 详情 详情
(V) 30782 (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-pyrrolidinecarboxylic acid C12H19NO4 详情 详情
(VI) 30783 3,3-diphenyl-1-propanethiol; 3,3-diphenylpropylhydrosulfide C15H16S 详情 详情
Extended Information