(6R,7S)-7-[(2-bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】30738

【品名】(6R,7S)-7-[(2-bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

【CA登记号】

【分子式】C₁₃H₁₅BrN₆O₅S₂

【分子量】479.33554

【元素组成】C 32.57% H 3.15% Br 16.67% N 17.53% O 16.69% S 13.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

A new method for the synthesis of MT-141 has been reported: By condensation of 7-bromoacetamido-7alpha-methoxy-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (I) with D-cysteine (II) in aqueous NaHCO3.

参考文献中间体

合成目标

【1】 Ogino, H.; Omoto, S.; Tsuruoka, T.; Miyauchi, K.; Niida, T.; Inouye, S.; Mizutani, K.; Iwamatsu, K.; Watanabe, T.; Synthesis and biological activity of 7beta-(2-amino-2-carboxy)-ethylthioacetamido-7alpha-methoxycephalosporin derivatives. J Antibiot 1983, 36, 3, 229-241.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30738	(6R,7S)-7-[(2-bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid		C₁₃H₁₅BrN₆O₅S₂	详情	详情
(II)	25404	D-cysteine; (S)-2-Amino-3-mercaptopropionic acid	921-01-7	C₃H₇NO₂S	详情	详情

Extended Information