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【结 构 式】

【分子编号】30445

【品名】1-chloro-7-methoxy-9H-thioxanthen-9-one

【CA登记号】

【 分 子 式 】C14H9ClO2S

【 分 子 量 】276.74296

【元素组成】C 60.76% H 3.28% Cl 12.81% O 11.56% S 11.59%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The bromination of 3-methoxybenzoic acid (I) with Br2 in refluxing acetic acid gives 2-bromo-5-methoxybenzoic acid (II), which is condensed with 3-chlorothiophenol (III) by means of cupric acetate in DMF at 150 C yielding the sulfide (IV). The cyclization of (IV) in sulfuric acid affords the thioxanthenone (V), which is condensed with 2-(diethylamino)ethylamine (VI) in pyridine at 115 C giving the corresponding 2-(diethylamino)ethylamino derivative (VII). The hydroxymethylation of (VII) with formaldehyde in hot 5N acetic acid yields the hydroxymethyl derivative (VIII), which is oxidized with MnO2 in hot toluene affording the corresponding aldehyde (IX). Finally, this compound is treated with formamide and formic acid at 170 C.

1 Perni, R.B.; Wentland, M.P.; Huang, J.I.; Powles, R.G.; Aldous, S.; Klingbeil, K.M.; Peverly, A.D.; Robinson, R.G.; Corbett, T.H.; Jones, J.L.; Mattes, K.C.; Rake, J.B.; Coughlin, S.A.; Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives. J Med Chem 1998, 41, 19, 3645.
2 Miller, T.C.; Collins, J.C.; Wentland, M.P.; Perni, R.B.; Corbett, T.H.; Mattes, K.C. (Sanofi-Synthelabo); Thioxanthenone antitumor agents. EP 0518414; EP 0619315; EP 0882723; JP 1993178853; JP 1994340655; US 5346917 .
3 Wentland, M.P.; et al.; Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives. Bioorg Med Chem Lett 1994, 4, 4, 609.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28559 m-Anisic acid; 3-Methoxybenzoic acid 586-38-9 C8H8O3 详情 详情
(II) 17819 2-bromo-5-methoxybenzoic acid 22921-68-2 C8H7BrO3 详情 详情
(III) 30443 3-chlorophenylhydrosulfide; 3-chlorobenzenethiol 2037-31-2 C6H5ClS 详情 详情
(IV) 30444 2-[(3-chlorophenyl)sulfanyl]-5-methoxybenzoic acid C14H11ClO3S 详情 详情
(V) 30445 1-chloro-7-methoxy-9H-thioxanthen-9-one C14H9ClO2S 详情 详情
(VI) 12420 N-(2-Aminoethyl)-N,N-diethylamine; N,N-Diethylethylene-diamine; N(1),N(1)-Diethyl-1,2-ethanediamine 100-36-7 C6H16N2 详情 详情
(VII) 30446 1-[[2-(diethylamino)ethyl]amino]-7-methoxy-9H-thioxanthen-9-one C20H24N2O2S 详情 详情
(VIII) 30447 1-[[2-(diethylamino)ethyl]amino]-4-(hydroxymethyl)-7-methoxy-9H-thioxanthen-9-one C21H26N2O3S 详情 详情
(IX) 30448 1-[[2-(diethylamino)ethyl]amino]-7-methoxy-9-oxo-9H-thioxanthene-4-carbaldehyde C21H24N2O3S 详情 详情
Extended Information