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【结 构 式】

【分子编号】37836

【品名】 

【CA登记号】

【 分 子 式 】C67H111N5O16Si2

【 分 子 量 】1298.81344

【元素组成】C 61.96% H 8.61% N 5.39% O 19.71% Si 4.32%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVI)

Hydrogenolysis of the Cbz group from the fully protected tetrapeptide (XIV) gave the free amine (XV). This was coupled with the activated ester (XIII) to provide the linear precursor (XVI). Selective cleavage of the silylethoxymethyl ester of (XVI) with MgBr2.Et2O, followed by hydrogenolysis of the Cbz group furnished (XVII). Subsequent macrocyclization of (XVII) using HATU afforded the cyclic depsipeptide (XVIII).

1 Liang, B.; et al.; The first total synthesis of (-)-tamadarin A. Org Lett 1999, 1, 8, 1319.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 37833 (1S)-2-methyl-1-[(2,3,4,5,6-pentafluorophenoxy)carbonyl]propyl (3S,4S,5S)-4-[[(benzyloxy)carbonyl]amino]-5-methyl-3-[(triisopropylsilyl)oxy]heptanoate C36H50F5NO7Si 详情 详情
(XIV) 37834 [2-(trimethylsilyl)ethoxy]methyl (2S,3R)-3-[[(2S)-2-[[[(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-4-methylpentanoyl)pyrrolidinyl]carbonyl](methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butanoate C45H68N4O12Si 详情 详情
(XV) 37835 [2-(trimethylsilyl)ethoxy]methyl (2S,3R)-3-[[(2S)-2-[([(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidinyl]carbonyl)(methyl)amino]-3-(4-methoxyphenyl)propanoyl]oxy]-2-[(tert-butoxycarbonyl)amino]butanoate C37H62N4O10Si 详情 详情
(XVI) 37836   C67H111N5O16Si2 详情 详情
(XVII) 37837   C53H91N5O13Si 详情 详情
(XVIII) 37838   C53H89N5O12Si 详情 详情
Extended Information