|
【结 构 式】 
|
【分子编号】35439 【品名】(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-3,10-dihydro-1-perylenyl]-1-methylethyl benzoate 【CA登记号】 |
【 分 子 式 】C44H38O12 【 分 子 量 】758.77852 【元素组成】C 69.65% H 5.05% O 25.3% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Intermediate (XII) is selectively demethylated with MgI2 to afford Calpostin A (XIII). Finally, this compound is debenzoylated with NaOMe in methanol to give Calpostin D.
| 【1】 Merlic, C.A.; et al.; Total synthesis of the calphostins: Application of fischer carbene complexes and thermodynamic control of atropisomers. J Org Chem 2001, 66, 4, 1297. |
| 【2】 Merlic, C.A.; et al.; Carbene complexes in the synthesis of complex natural products: Total synthesis of the calphostins. J Am Chem Soc 2000, 122, 13, 3224. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 35435 | (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-2,4,6,7,9,11-hexamethoxy-3,10-dioxo-3,10-dihydro-1-perylenyl]-1-methylethyl benzoate | C46H42O12 | 详情 | 详情 | |
| (XIII) | 35439 | (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-3,10-dihydro-1-perylenyl]-1-methylethyl benzoate | C44H38O12 | 详情 | 详情 |
Extended Information