|
【结 构 式】 
|
【分子编号】31586 【品名】1-[[tert-butyl(dimethyl)silyl]oxy]-2-butanone 【CA登记号】 |
【 分 子 式 】C10H22O2Si 【 分 子 量 】202.36898 【元素组成】C 59.35% H 10.96% O 15.81% Si 13.88% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXII)The reaction of 2-methylpropane-1,3-dial (XX) first with methanesulfonyl chloride and then with NaOMe gives 3-methoxy-2-methyl-2-propenal (XXI), which is cyclized with 1-(tert-butyldimethylsilyloxy)-2-butanone (XXII) in basic medium to yield the dihydropyridine (XXIII). Finally, this compound is dehydrogenated with DDQ and desilylated to afford the target intermediate 4-methoxy-3,5-dimethylpyridine-2-methanol (VI).
| 【1】 Bekhazi, M.; Zoghbi, M. (PDi-Research Laboratories, Inc. ); Synthesis of omeprazole-type pyridine derivs. and intermediates thereof. WO 9729103 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 18785 | (4-methoxy-3,5-dimethyl-2-pyridinyl)methanol | C9H13NO2 | 详情 | 详情 | |
| (XX) | 31584 | 2-methylmalonaldehyde | C4H6O2 | 详情 | 详情 | |
| (XXI) | 31585 | (E)-3-methoxy-2-methyl-2-propenal | C5H8O2 | 详情 | 详情 | |
| (XXII) | 31586 | 1-[[tert-butyl(dimethyl)silyl]oxy]-2-butanone | C10H22O2Si | 详情 | 详情 | |
| (XXIII) | 31587 | 2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4-methoxy-3,5-dimethyl-1,4-dihydropyridine; tert-butyl(dimethyl)silyl (4-methoxy-3,5-dimethyl-1,4-dihydro-2-pyridinyl)methyl ether | C15H29NO2Si | 详情 | 详情 |
Extended Information