• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】30405

【品名】2-(2-chloroethoxy)acetonitrile

【CA登记号】

【 分 子 式 】C4H6ClNO

【 分 子 量 】119.55048

【元素组成】C 40.19% H 5.06% Cl 29.66% N 11.72% O 13.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The resolution of racemic 1-[(4-chlorophenyl)phenylmethyl]piperazine (I) with L-tartaric acid provided the required (R)-enantiomer (II), which was condensed with (2-chloroethoxy)acetonitrile (III) in the presence of Na2CO3 and KI in refluxing n-butanol to give the alkylated piperazine (IV). The nitrile group of (IV) was finally hydrolyzed by means of concentrated hydrochloric acid to yield the target carboxylic acid.

1 Cossement, E.; Motte, G.; Gobert, J.; Bodson, G. (UCB SA); Process for preparation of a 1-piperazine-ethoxyacetic acid. GB 2225321 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28775 p-Chloro benzhydryl piperazine; 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine; N-(Chloro-1-benzhydryl)piperazine; 1-(4-Chlorobenzhydryl)piperazine 303-26-4 C17H19ClN2 详情 详情
(II) 30404 1-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazine C17H19ClN2 详情 详情
(III) 30405 2-(2-chloroethoxy)acetonitrile C4H6ClNO 详情 详情
(IV) 30406 2-(2-[4-[(R)-(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl]ethoxy)acetonitrile C21H24ClN3O 详情 详情
Extended Information