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【结 构 式】

【分子编号】30400

【品名】tert-butyl (1S)-1-[4-(benzyloxy)benzyl]-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-2-thioxoethylcarbamate

【CA登记号】

【 分 子 式 】C28H28FN3O4S

【 分 子 量 】521.6125432

【元素组成】C 64.47% H 5.41% F 3.64% N 8.06% O 12.27% S 6.15%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(V)

Coupling of N-Boc-O-benzyltyrosine (I) with 4-fluoro-1,2-phenylenediamine (II) by means of EDC afforded amide (III), which was converted into thioamide (IV) upon treatment with phosphorus pentasulfide and Na2CO3. Then, ring closure of (IV) with phosgene afforded the benzimidazolone derivative (V).

1 Zackarie, B.; et al.; Thioamides: Synthesis, stability, and immunological activities of thioanalogues of imreg. Preparation Of new thioacylating agents using fluorobenzimidazolone derivatives. J Med Chem 1999, 42, 11, 2046.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 30396 (2S)-3-[4-(benzyloxy)phenyl]-2-[(tert-butoxycarbonyl)amino]propionic acid 54784-43-9 C21H25NO5 详情 详情
(II) 30397 2-amino-4-fluorophenylamine; 4-fluoro-1,2-benzenediamine 367-31-7 C6H7FN2 详情 详情
(III) 30398 tert-butyl (1S)-2-(2-amino-5-fluoroanilino)-1-[4-(benzyloxy)benzyl]-2-oxoethylcarbamate C27H30FN3O4 详情 详情
(IV) 30399 tert-butyl (1S)-2-(2-amino-5-fluoroanilino)-1-[4-(benzyloxy)benzyl]-2-thioxoethylcarbamate C27H30FN3O3S 详情 详情
(V) 30400 tert-butyl (1S)-1-[4-(benzyloxy)benzyl]-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-2-thioxoethylcarbamate C28H28FN3O4S 详情 详情

合成路线2

该中间体在本合成路线中的序号:(V)

Coupling of N-Boc-glycine (VI) with glycine benzyl ester hydrochloride (VII) by means of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ) gave the protected dipeptide (VIII). After deprotection of the Boc group of (VIII) with HCl, the resulting amine (IX) was condensed with the thioacylating compound (V) to furnish thioamide (X). Finally, the Boc and benzyl protecting groups of (X) were cleaved using HF.

1 Zackarie, B.; et al.; Thioamides: Synthesis, stability, and immunological activities of thioanalogues of imreg. Preparation Of new thioacylating agents using fluorobenzimidazolone derivatives. J Med Chem 1999, 42, 11, 2046.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 30400 tert-butyl (1S)-1-[4-(benzyloxy)benzyl]-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-2-thioxoethylcarbamate C28H28FN3O4S 详情 详情
(VI) 18066 N-alpha-t-BOC-glycine; 2-[(tert-butoxycarbonyl)amino]acetic acid 4530-20-5 C7H13NO4 详情 详情
(VII) 13601 benzyl 2-aminoacetate; Glycine benzyl ester hydrochloride 1738-68-7 C9H11NO2 详情 详情
(VIII) 30401 benzyl 2-([2-[(tert-butoxycarbonyl)amino]acetyl]amino)acetate C16H22N2O5 详情 详情
(IX) 30402 benzyl 2-[(2-aminoacetyl)amino]acetate C11H14N2O3 详情 详情
(X) 30403 benzyl (6S)-6-[4-(benzyloxy)benzyl]-2,2-dimethyl-4,10-dioxo-7-thioxo-3-oxa-5,8,11-triazatridecan-13-oate C32H37N3O6S 详情 详情
Extended Information