• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】30394

【品名】2-(9-anthrylmethyl)-1H-isoindole-1,3(2H)-dione

【CA登记号】

【 分 子 式 】C23H15NO2

【 分 子 量 】337.37764

【元素组成】C 81.88% H 4.48% N 4.15% O 9.48%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

Reaction of 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile (I) with 1,3-dibromopropane (II) in the presence of n-butyllithium at -78 C provided bromonitrile (III). Alkylation of potassium phthalimide (V) with 9-(chloromethyl)anthracene (IV) yielded the N-alkylated phthalimide (VI), and subsequent hydrazinolysis gave the aminomethyl compound (VIII). Finally, amine (VIII) was alkylated with bromide (III) in Et3N at 60 C to produce the title compound, which was isolated as the corresponding hydrochloride salt.

1 Teodori, E.; Dei, S.; Quidu, P.; et al.; Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: Discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range. J Med Chem 1999, 42, 10, 1687.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 30391 2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile; alpha-Isopropylveratryl cyanide 20850-49-1 C13H17NO2 详情 详情
(II) 12581 1,3-Dibromopropane 109-64-8 C3H6Br2 详情 详情
(III) 30392 5-bromo-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile C16H22BrNO2 详情 详情
(IV) 30393 9-(chloromethyl)anthracene 24463-19-2 C15H11Cl 详情 详情
(V) 27890 Potassium phthalimide 1074-82-4 C8H4KNO2 详情 详情
(VI) 30394 2-(9-anthrylmethyl)-1H-isoindole-1,3(2H)-dione C23H15NO2 详情 详情
(VII) 30395 9-anthrylmethanamine; 9-anthrylmethylamine 2476-68-8 C15H13N 详情 详情
Extended Information