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【结 构 式】

【分子编号】30362

【品名】2-oxopropanal oxime

【CA登记号】306-44-5

【 分 子 式 】C3H5NO2

【 分 子 量 】87.07824

【元素组成】C 41.38% H 5.79% N 16.09% O 36.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The oxidation of acetone (I) with butyl nitrite (II) with a catalytic amount of HCl gives methylglyoxal 1-oxime (III), which is then condensed with aminoguanidine (IV) in hot water acidified with HCl.

1 Nagaki, D.; Nishimura, T.; Hasegawa, K.; Toku, H.; Sakaguchi, H.; Yamazaki, C.; Antiviral compounds. IX. Synthesis and anti-influenza virus activity of bis-amidinohydrazones of glyoxal and methylglyoxal. Kitasato Arch Exp Med 1975, 48, 4, 171-181.
2 Serradell, M.N.; Eastland, G.W.; Castaner, J.; Mitoguazone. Drugs Fut 1984, 9, 3, 199.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23199 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one; Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether 67-64-1 C3H6O 详情 详情
(II) 31340 butyl nitrite 544-16-1 C4H9NO2 详情 详情
(III) 30362 2-oxopropanal oxime 306-44-5 C3H5NO2 详情 详情
(IV) 10015 1-Hydrazinecarboximidamide; Hydrazinecarboximidamide 79-17-4 CH6N4 详情 详情
Extended Information