【结 构 式】 |
【分子编号】30362 【品名】2-oxopropanal oxime 【CA登记号】306-44-5 |
【 分 子 式 】C3H5NO2 【 分 子 量 】87.07824 【元素组成】C 41.38% H 5.79% N 16.09% O 36.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The oxidation of acetone (I) with butyl nitrite (II) with a catalytic amount of HCl gives methylglyoxal 1-oxime (III), which is then condensed with aminoguanidine (IV) in hot water acidified with HCl.
【1】 Nagaki, D.; Nishimura, T.; Hasegawa, K.; Toku, H.; Sakaguchi, H.; Yamazaki, C.; Antiviral compounds. IX. Synthesis and anti-influenza virus activity of bis-amidinohydrazones of glyoxal and methylglyoxal. Kitasato Arch Exp Med 1975, 48, 4, 171-181. |
【2】 Serradell, M.N.; Eastland, G.W.; Castaner, J.; Mitoguazone. Drugs Fut 1984, 9, 3, 199. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 23199 | 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one; Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether | 67-64-1 | C3H6O | 详情 | 详情 |
(II) | 31340 | butyl nitrite | 544-16-1 | C4H9NO2 | 详情 | 详情 |
(III) | 30362 | 2-oxopropanal oxime | 306-44-5 | C3H5NO2 | 详情 | 详情 |
(IV) | 10015 | 1-Hydrazinecarboximidamide; Hydrazinecarboximidamide | 79-17-4 | CH6N4 | 详情 | 详情 |
Extended Information