【结 构 式】 |
【分子编号】30354 【品名】ethyl 2-(4-[2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy]phenyl)acetate 【CA登记号】 |
【 分 子 式 】C23H31NO4 【 分 子 量 】385.50348 【元素组成】C 71.66% H 8.11% N 3.63% O 16.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The addition of N-benzyl-3-phenyl-1-methylpropylamine (I) to ethyl 4-(2,3-oxidopropoxy)phenylacetate (II) in refluxing ethanol, followed by debenzylation with H2 over Pd/C gives 1-[4-(ethoxycarbonylmethyl)phenoxyl-3-(1-methyl-3-phenylpropylamino)-2-propanol (III), which is then treated with NH3 in ethanol.
【1】 Takizawa, H.; Oiji, Y.; Kubo, K. (Kyowa Hakko Kogyo Co., Ltd.); Amino-alcohol derivatives. DE 3010752; US 4381398 . |
【2】 Castaner, J.; Serradell, M.N.; KF-4317. Drugs Fut 1984, 9, 3, 189. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 30352 | ethyl 2-[4-(2-oxiranylmethoxy)phenyl]acetate | C13H16O4 | 详情 | 详情 | |
(II) | 30353 | N-benzyl-N-(1-methyl-3-phenylpropyl)amine; N-(4-phenyl-2-butyl)benzylamine; N-benzyl-4-phenyl-2-butanamine | C17H21N | 详情 | 详情 | |
(III) | 30354 | ethyl 2-(4-[2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy]phenyl)acetate | C23H31NO4 | 详情 | 详情 |
Extended Information