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【结 构 式】 
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【分子编号】30247 【品名】(1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-12-((E)-2-[(1R,3R,4R)-4-[(chlorocarbonyl)oxy]-3-methoxycyclohexyl]-1-methylethenyl)-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.0(4,9)]octacos-18-ene 【CA登记号】 |
【 分 子 式 】C44H68ClNO13 【 分 子 量 】854.47556 【元素组成】C 61.85% H 8.02% Cl 4.15% N 1.64% O 24.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The title compound was obtained by treatment of ascomycin (I) with triphosgene and 4-dimethylaminopyridine at -78 C to produce selectively the 32-hydroxyl mono-acylated product (II), which was subsequently condensed with phenylhydrazine yielding the target phenylcarbazate.
| 【1】 Hersperger, R.; et al.; Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin. Bioorg Med Chem Lett 1999, 9, 2, 227. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14951 | (1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(4,9)]octacos-18-ene-2,3,10,16-tetron | C43H69NO12 | 详情 | 详情 | |
| (II) | 30247 | (1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-12-((E)-2-[(1R,3R,4R)-4-[(chlorocarbonyl)oxy]-3-methoxycyclohexyl]-1-methylethenyl)-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.0(4,9)]octacos-18-ene | C44H68ClNO13 | 详情 | 详情 |
Extended Information