【结 构 式】 |
【分子编号】30133 【品名】4-(2-methoxy-2-oxoethyl)-8-nitro-1-naphthalenesulfonic acid 【CA登记号】 |
【 分 子 式 】C13H11NO7S 【 分 子 量 】325.29888 【元素组成】C 48% H 3.41% N 4.31% O 34.43% S 9.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XVI)Sulfonation of methyl naphthylacetate (XIV) gave sulfonate (XV), which was nitrated at -20 C to produce (XVI) as the major isomer. Reduction of the nitro group of (XVI) employing iron and H2SO4 yielded aminosulfonate (XVII), which was cyclized by means of POCl3 to give sultam (XVIII). The ester group of (XVIII) was finally reduced to alcohol (VII) with LiAlH4.
【1】 Wilkening, R.R.; Ratcliffe, R.W.; Blizzard, T.A. (Merck & Co., Inc.); Carbapenem antibacterial cpds., compsns. containing such cpds. and methods of treatment. EP 0906313; JP 1999508279; US 5756725; WO 9740048 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 30123 | 6-(2-hydroxyethyl)-2H-naphtho[1,8-cd]isothiazole-1,1(2H)-dione | C12H11NO3S | 详情 | 详情 | |
(XIV) | 30131 | methyl 2-(1-naphthyl)acetate | 2876-78-0 | C13H12O2 | 详情 | 详情 |
(XV) | 30132 | potassium 4-(2-methoxy-2-oxoethyl)-1-naphthalenesulfonate | C13H11KO5S | 详情 | 详情 | |
(XVI) | 30133 | 4-(2-methoxy-2-oxoethyl)-8-nitro-1-naphthalenesulfonic acid | C13H11NO7S | 详情 | 详情 | |
(XVII) | 30134 | sodium 8-amino-4-(2-methoxy-2-oxoethyl)-1-naphthalenesulfonate | C13H12NNaO5S | 详情 | 详情 | |
(XVIII) | 30135 | methyl 2-(1,1-dioxo-1,2-dihydro-2H-naphtho[1,8-cd]isothiazol-6-yl)acetate | C13H11NO4S | 详情 | 详情 |
Extended Information