|
【结 构 式】 
|
【分子编号】30002 【品名】5-fluoro-1,3-bis(trimethylsilyl)-2,4(1H,3H)-pyrimidinedione 【CA登记号】 |
【 分 子 式 】C10H19FN2O2Si2 【 分 子 量 】274.4425432 【元素组成】C 43.77% H 6.98% F 6.92% N 10.21% O 11.66% Si 20.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of bis(trimethylsilyl)fluorouracil (I) with 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose (II) in the presence of trimethylsilyl trifluoromethanesulfonate (III) gives the fully protected compound (IV), which is finally deprotected by the usual methods.
| 【1】 D'Souza, R.; Arnold, W.; Van Koeveringe, J.A.; Kiss, J.; Stereospecific synthesis of the anticancer agent 5'-deoxy-5-fluorouridine (5-DFUR) and its 5'-deuterated derivatives. Helv Chim Acta 1982, 65, 5, 1522. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 30002 | 5-fluoro-1,3-bis(trimethylsilyl)-2,4(1H,3H)-pyrimidinedione | C10H19FN2O2Si2 | 详情 | 详情 | |
| (II) | 16748 | (2R,3R,4R,5S)-4,5-bis(acetoxy)-2-methyltetrahydro-3-furanyl acetate | 62211-93-2 | C11H16O7 | 详情 | 详情 |
| (III) | 30003 | trifluoromethyl (trimethylsilyl)methyl sulfone; trimethyl[[(trifluoromethyl)sulfonyl]methyl]silane | C5H11F3O2SSi | 详情 | 详情 | |
| (IV) | 30004 | (2R,3R,4R,5R)-4-(acetoxy)-2-[5-fluoro-2,4-dioxo-3-(trimethylsilyl)-3,4-dihydro-1(2H)-pyrimidinyl]-5-methyltetrahydro-3-furanyl acetate | C16H23FN2O7Si | 详情 | 详情 |
Extended Information