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【结 构 式】 
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【分子编号】29680 【品名】3,6-dichloro-2-[1-(1H-imidazol-1-yl)vinyl]phenyl 2-oxiranylmethyl ether; 1-[1-[3,6-dichloro-2-(2-oxiranylmethoxy)phenyl]vinyl]-1H-imidazole 【CA登记号】 |
【 分 子 式 】C14H12Cl2N2O2 【 分 子 量 】311.16696 【元素组成】C 54.04% H 3.89% Cl 22.79% N 9% O 10.28% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)This 1-vinylimidazole compound (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with 2-hydroxy-3,6-dichloroacetophenone (I) in dichloro-methane. Treatment of (II) with epibromohydrin (B) in DMF in the presence of NaH gives the epoxy compound (III), which is then treated with isopropylamine (C) to obtain the propanolamine compound (IV). The hydrochloride can be prepared by treatment of the free base (IV) with one molar equivalent of HCl in AcOEt.
| 【1】 Kida, S.; Ueda, M.; Kimoto, S.; Haruna, M.; Matsumoto, H.; Takahashi, K.; Ogata, M.; Synthesis and antiarrhythmic activity of new 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-imidazoles and related compounds. J Med Chem 1984, 27, 9, 1142. |
| 【2】 Ueda, M.; 711389-S. Drugs Fut 1985, 10, 6, 472. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 29655 | 1-(1H-imidazol-1-ylsulfinyl)-1H-imidazole | C6H6N4OS | 详情 | 详情 | |
| (B) | 29679 | 2-(bromomethyl)oxirane | 3132-64-7 | C3H5BrO | 详情 | 详情 |
| (I) | 29677 | 1-(3,6-dichloro-2-hydroxyphenyl)-1-ethanone | C8H6Cl2O2 | 详情 | 详情 | |
| (II) | 29678 | 3,6-dichloro-2-[1-(1H-imidazol-1-yl)vinyl]phenol | C11H8Cl2N2O | 详情 | 详情 | |
| (III) | 29680 | 3,6-dichloro-2-[1-(1H-imidazol-1-yl)vinyl]phenyl 2-oxiranylmethyl ether; 1-[1-[3,6-dichloro-2-(2-oxiranylmethoxy)phenyl]vinyl]-1H-imidazole | C14H12Cl2N2O2 | 详情 | 详情 | |
| (IV) | 29681 | 1-[3,6-dichloro-2-[1-(1H-imidazol-1-yl)vinyl]phenoxy]-3-(isopropylamino)-2-propanol | C17H21Cl2N3O2 | 详情 | 详情 | |
| (C) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
Extended Information