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【结 构 式】 
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【分子编号】29661 【品名】8-(2-pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane bromide 【CA登记号】 |
【 分 子 式 】C12H19BrN4 【 分 子 量 】299.21382 【元素组成】C 48.17% H 6.4% Br 26.7% N 18.72% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The quaternary salt (II), prepared from 1-(pyrimidin-2-yl)piperazine (I) and 1,4-dibromobutane (A), undergoes reaction with 3,3-dimethylglutarimide (III) in the presence of potassium carbonate in refluxing xylene to afford the free base (IV), which is isolated by acid extraction and basification of the extract. Treatment of the free base with HCl in isopropanol affords ttle compound as the monohydrochloride.
| 【1】 Temple, D.L. Jr. (Bristol-Myers Squibb Co.); 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines. BE 0895504; CH 656383; DE 3248160; FR 2518993; GB 2114122; JP 1983118582; JP 1994293753; US 4423049 . |
| 【2】 Eison, M.S.; Yevich, J.P.; Farney, R.F.; Gepirone Hydrochloride. Drugs Fut 1985, 10, 6, 456. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 11883 | 1,4-Dibromobutane; 1,4-Butylene bromide | 110-52-1 | C4H8Br2 | 详情 | 详情 |
| (I) | 11175 | 2-(1-Piperazinyl)pyrimidine; 2-Piperazinopyrimidine; N-(Pyrimidinyl)piperazine | 20980-22-7 | C8H12N4 | 详情 | 详情 |
| (II) | 29661 | 8-(2-pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane bromide | C12H19BrN4 | 详情 | 详情 | |
| (III) | 29662 | 4,4-dimethyl-2,6-piperidinedione | 1123-40-6 | C7H11NO2 | 详情 | 详情 |
Extended Information