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【结 构 式】

【分子编号】29392

【品名】tert-butyl 2-(aminocarbonyl)-1-hydrazinecarboxylate

【CA登记号】

【 分 子 式 】C6H13N3O3

【 分 子 量 】175.18764

【元素组成】C 41.14% H 7.48% N 23.99% O 27.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The compound was prepared by solid-phase synthesis. Condensation of tert-butyl carbazate (I) with 1,1'-carbonyldiimidazole (II) afforded the acyl imidazole (III). Coupling of (III) with amino resin produced the Boc-protected semicarbazide-linked resin (IV), which was deprotected with trifluoroacetic acid to give (V). Condensation of (V) with protected L-argininal (VI) provided the semicarbazone resin (VII). Further solid-phase peptide synthesis by means of sequential coupling with L-alanine, D-serine and phenethylsulfonyl chloride yielded the peptide-resin (VIII). Finally, deprotection of both Boc groups of (VIII) with concomitant resin cleavage by means of aqueous trifluoroacetic acid furnished the target compound.

1 Cohen, C.R.; Weinhouse, M.I.; Roberts, C.; et al.; Synthesis and biological activity of transition-state urokinase inhibitors. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 090.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10893 tert-butyl 1-hydrazinecarboxylate; tert-butyl carbazate 870-46-2 C5H12N2O2 详情 详情
(II) 11353 1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole) 530-62-1 C7H6N4O 详情 详情
(III) 29391 tert-butyl 2-(1H-imidazol-1-ylcarbonyl)-1-hydrazinecarboxylate C9H14N4O3 详情 详情
(IV) 29392 tert-butyl 2-(aminocarbonyl)-1-hydrazinecarboxylate C6H13N3O3 详情 详情
(V) 23944 1-Hydrazinecarboxamide 563-41-7 CH5N3O 详情 详情
(VI) 29393 9H-fluoren-9-ylmethyl (1S)-4-([[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl]amino)-1-formylbutylcarbamate C31H40N4O7 详情 详情
(VII) 29394 tert-butyl (Z)-[((4S)-5-[(E)-2-(aminocarbonyl)hydrazono]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pentyl)amino][(tert-butoxycarbonyl)amino]methylidenecarbamate C32H43N7O7 详情 详情
(VIII) 29395 tert-butyl (Z,6S,9S,12R)-6-[[(E)-2-(aminocarbonyl)hydrazono]methyl]-1-[(tert-butoxycarbonyl)amino]-12-(hydroxymethyl)-9-methyl-8,11,14,14-tetraoxo-16-phenyl-14lambda(6)-thia-2,7,10,13-tetraazahexadec-1-ylidenecarbamate C31H51N9O10S 详情 详情
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