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【结 构 式】 
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【分子编号】29382 【品名】isobutyl (1R)-2-[[(1S)-2-([(3S)-1-[amino(imino)methyl]-2-[(6-amino-6-oxohexyl)oxy]piperidinyl]amino)-1-methyl-2-oxoethyl]amino]-1-(hydroxymethyl)-2-oxoethylcarbamate 【CA登记号】 |
【 分 子 式 】C23H43N7O7 【 分 子 量 】529.6374 【元素组成】C 52.16% H 8.18% N 18.51% O 21.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)Further solid-phase peptide synthesis by means of sequential coupling of resin (IX) with L-alanine, D-serine and isobutyl chloroformate yielded the peptide-resin (X). The allyloxycarbonyl group of (X) was then removed by treatment with morpholine and palladium catalyst to give resin (XI). The target peptide was finally liberated from the resin (XI) by treatment with trifluoroacetic acid.
| 【1】 Cohen, C.R.; Weinhouse, M.I.; Roberts, C.; et al.; Synthesis and biological activity of transition-state urokinase inhibitors. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 090. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 29380 | allyl (E)-amino[(3S)-2-[(6-amino-6-oxohexyl)oxy]-3-[(tert-butoxycarbonyl)amino]piperidinyl]methylidenecarbamate | C21H37N5O6 | 详情 | 详情 | |
| (X) | 29381 | allyl (E)-amino((3S)-2-[(6-amino-6-oxohexyl)oxy]-3-[[(2S)-2-([(2R)-3-hydroxy-2-[(isobutoxycarbonyl)amino]propanoyl]amino)propanoyl]amino]piperidinyl)methylidenecarbamate | C27H47N7O9 | 详情 | 详情 | |
| (XI) | 29382 | isobutyl (1R)-2-[[(1S)-2-([(3S)-1-[amino(imino)methyl]-2-[(6-amino-6-oxohexyl)oxy]piperidinyl]amino)-1-methyl-2-oxoethyl]amino]-1-(hydroxymethyl)-2-oxoethylcarbamate | C23H43N7O7 | 详情 | 详情 |
Extended Information