N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine C-1,6-N-5,2 cyclic lactam -Drug Synthesis Database

【结构式】

【分子编号】29347

【品名】N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine C-1,6-N-5,2 cyclic lactam

【CA登记号】

【分子式】C₆₀H₇₃N₁₁O₈

【分子量】1076.30896

【元素组成】C 66.96% H 6.84% N 14.32% O 11.89%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Cleavage from the resin (XI) using anhydrous HF in the presence of thiocresol furnished the linear peptide (XII). This was cyclized employing BOP and diisopropylethylamine in DMF to give the cyclic peptide (XIII). The Fmoc group of (XIII) was finally deprotected by means of piperidine in DMF.

参考文献中间体

合成目标

【1】 Wong, A.K.; Shields, I.A.; Taylor, S.M.; Short, A.; Fairlie, D.P.; Haaima, G.; Finch, A.M.; Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Br J Pharmacol 1999, 126, 3, 551.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XI)	29345	Fluorenylmethoxycarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-D-cyclohexylalanyl-L-tryptophyl-L-(Nomega-tosyl)arginine	C₆₇H₈₁N₁₁O₁₁S	详情	详情
(XII)	29346	N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine	C₆₀H₇₅N₁₁O₉	详情	详情
(XIII)	29347	N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine C-1,6-N-5,2 cyclic lactam	C₆₀H₇₃N₁₁O₈	详情	详情

Extended Information