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【结 构 式】

【分子编号】29347

【品名】N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine C-1,6-N-5,2 cyclic lactam

【CA登记号】

【 分 子 式 】C60H73N11O8

【 分 子 量 】1076.30896

【元素组成】C 66.96% H 6.84% N 14.32% O 11.89%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIII)

Cleavage from the resin (XI) using anhydrous HF in the presence of thiocresol furnished the linear peptide (XII). This was cyclized employing BOP and diisopropylethylamine in DMF to give the cyclic peptide (XIII). The Fmoc group of (XIII) was finally deprotected by means of piperidine in DMF.

1 Wong, A.K.; Shields, I.A.; Taylor, S.M.; Short, A.; Fairlie, D.P.; Haaima, G.; Finch, A.M.; Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Br J Pharmacol 1999, 126, 3, 551.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XI) 29345 Fluorenylmethoxycarbonyl-L-phenylalanyl-L-ornithyl-L-prolyl-D-cyclohexylalanyl-L-tryptophyl-L-(Nomega-tosyl)arginine C67H81N11O11S 详情 详情
(XII) 29346 N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine C60H75N11O9 详情 详情
(XIII) 29347 N-(Fluoren-9-ylmethoxycarbonyl)-L-phenylalanyl-L-ornithyl-L-prolyl-L-cyclohexylalanyl-L-tryptophyl-L-arginine C-1,6-N-5,2 cyclic lactam C60H73N11O8 详情 详情
Extended Information