(4-chlorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol -Drug Synthesis Database

【结构式】

【分子编号】29311

【品名】(4-chlorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

【CA登记号】

【分子式】C₁₇H₁₈ClNO₃

【分子量】319.78756

【元素组成】C 63.85% H 5.67% Cl 11.09% N 4.38% O 15.01%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The Grignard reaction of 2,2,8-trimethyl-5-formylpyrido[4,3-e]-1,3-dioxane (I) with 4-chlorophenyl magnesium bromide (II) in refluxing ether gives 2,2,8-trimethyl-5-(4-chloro-alpha-hydroxybenzyl)pyrido[4,3-e]-1,3-dioxane (III), which is then hydrolyzed and cyclized by a treatment with aqueous concentrated HCl

参考文献中间体

合成目标

【1】 Esanu, A (SCRAS (Societe de Conseils de Recherches et d'Applications Scientifiques)); Furo[3,4-c]pyridine derivatives and their pharmaceutical use. BE 0891797; DE 3204596; FR 2499406; FR 2499574; GB 2092586; JP 82150688; US 4383998 .
【2】 Castaner, J.; Serradell, M.N.; Thorpe, P.; Cycletanide. Drugs Fut 1985, 10, 5, 378.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28771	2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carbaldehyde		C₁₁H₁₃NO₃	详情	详情
(II)	25127	bromo(4-chlorophenyl)magnesium	873-77-8	C₆H₄BrClMg	详情	详情
(III)	29311	(4-chlorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol		C₁₇H₁₈ClNO₃	详情	详情

Extended Information