butyl 2-bromoacetate -Drug Synthesis Database

【结构式】

【分子编号】29300

【品名】butyl 2-bromoacetate

【CA登记号】

【分子式】C₃₂H₃₂ClN₃O₂

【分子量】526.0778

【元素组成】C 73.06% H 6.13% Cl 6.74% N 7.99% O 6.08%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

4-Amino-5-chloro-2-methoxybenzoic acid (I) was converted to the mixed anhydride (II) upon treatment with ethyl chloroformate and Et3N. Subsequent coupling of (II) with 4-amino-1-tritylpiperidine (III) afforded amide (IV). The trityl group of (IV) was then removed by acidic treatment to give piperidine (V). Finally, alkylation of (V) with butyl bromoacetate (VI) furnished the title compound.

参考文献中间体

合成目标

【1】 Ito, Y.; Kato, H.; Yasuda, S.; Iwasaki, N.; Nishino, H.; Takeshita, M. (Hokuriku Seiyaku Co., Ltd.); Benzamide deriv.. EP 0640601; US 5395832; US 5500422; WO 9214705 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12419	4-Amino-5-chloro-2-methoxybenzoic acid	7206-70-4	C₈H₈ClNO₃	详情	详情
(II)	29299	4-Amino-5-chloro-2-methoxybenzoic acid methoxycarbonyl anhydride		C₁₀H₁₀ClNO₅	详情	详情
(III)	19955	1-trityl-4-piperidinylamine; 1-trityl-4-piperidinamine		C₂₄H₂₆N₂	详情	详情
(IV)	19956	4-amino-5-chloro-2-methoxy-N-(1-trityl-4-piperidinyl)benzamide		C₃₂H₃₂ClN₃O₂	详情	详情
(V)	19957	4-amino-5-chloro-2-methoxy-N-(4-piperidinyl)benzamide		C₁₃H₁₈ClN₃O₂	详情	详情
(VI)	29300	butyl 2-bromoacetate		C₃₂H₃₂ClN₃O₂	详情	详情

Extended Information