4-([(2S,3S,5R)-3-azido-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methoxy)-2,3-dimethyl-4-oxobutyric acid -Drug Synthesis Database

【结构式】

【分子编号】29298

【品名】4-([(2S,3S,5R)-3-azido-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methoxy)-2,3-dimethyl-4-oxobutyric acid

【CA登记号】

【分子式】C₁₆H₂₁N₅O₇

【分子量】395.37224

【元素组成】C 48.61% H 5.35% N 17.71% O 28.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of azidothymidine (I) with 2,3-dimethylsuccinic anhydride (II) afforded amide (III). This was then coupled with amine (IV) using DCC and HOBt to furnish the title compound.

参考文献中间体

合成目标

【1】 Kiso, Y.; Kimura, T.; Akaji, K.; Matsuda, T.; Matsumoto, H.; Hamawaki, T.; A new class of potent anti-HIV agents, conjugates of HIV protease inhibitors containing carboxylic acid with reverse transcriptase inhibitor. Symp Med Chem 1998, Abst 1-P-17.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25317	1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione	101703-35-9	C₁₀H₁₃N₅O₄	详情	详情
(II)	29297	3,4-dimethyldihydro-2,5-furandione		C₆H₈O₃	详情	详情
(III)	29298	4-([(2S,3S,5R)-3-azido-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methoxy)-2,3-dimethyl-4-oxobutyric acid		C₁₆H₂₁N₅O₇	详情	详情
(IV)	29294	(4R)-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-N-(tert-butyl)-5,5-dimethyl-1,3-thiazolidine-4-carboxamide		C₂₀H₃₁N₃O₃S	详情	详情

Extended Information