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【结 构 式】 
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【分子编号】29296 【品名】4-[((1S,2S)-1-benzyl-3-[(4R)-4-[(tert-butylamino)carbonyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyric acid 【CA登记号】 |
【 分 子 式 】C26H39N3O6S 【 分 子 量 】521.67828 【元素组成】C 59.86% H 7.54% N 8.05% O 18.4% S 6.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The condensation of amine (I) with 2,2-dimethylsuccinic anhydride (II) afforded amide (III). This was then coupled with azidothymidine (IV) using DCC and DMAP to furnish the title compound.
| 【1】 Kiso, Y.; Kimura, T.; Akaji, K.; Matsuda, T.; Matsumoto, H.; Hamawaki, T.; A new class of potent anti-HIV agents, conjugates of HIV protease inhibitors containing carboxylic acid with reverse transcriptase inhibitor. Symp Med Chem 1998, Abst 1-P-17. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29294 | (4R)-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-N-(tert-butyl)-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | C20H31N3O3S | 详情 | 详情 | |
| (II) | 29295 | 3,3-dimethyldihydro-2,5-furandione | 17347-61-4 | C6H8O3 | 详情 | 详情 |
| (III) | 29296 | 4-[((1S,2S)-1-benzyl-3-[(4R)-4-[(tert-butylamino)carbonyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyric acid | C26H39N3O6S | 详情 | 详情 | |
| (IV) | 25317 | 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | 101703-35-9 | C10H13N5O4 | 详情 | 详情 |
Extended Information