【结 构 式】 |
【分子编号】29274 【品名】methyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate 【CA登记号】 |
【 分 子 式 】C13H16N2O2 【 分 子 量 】232.28232 【元素组成】C 67.22% H 6.94% N 12.06% O 13.78% |
合成路线1
该中间体在本合成路线中的序号:(IX)Synthesis of intermediate (VIII): Hydrogenation of m-cyanobenzoic acid (I) with H2 over Raney-Ni in ammonia gives amine (II), which is treated with Boc2O and NaOH in dioxane to provide protected amine (III). Reduction of (III) by means of PtO2 and H2 in acetic acid yields a 10:1 mixture of cis/trans ciclohexane derivatives (rac)-(IV)/(rac)-(V). The racemic cis compound obtained is enantiomerically resolved and stereomer (V) is then reduced with BH3.Me2S in THF providing alcohol (VI), which is converted into azide (VII) after treatment with NaN3 in DMF of the mesylate derivative obtained by treatment of (VI) with Et3N, DMAP and MsCl. Finally amino derivative (VIII) is obtained by hydrogenation of azide (VII) over Pd/C in MeOH. Synthesis of intermediate (XII): beta-Methyl-D-tryptophan methyl ester (IX) reacts with piperidine derivative (X) in presence of DSC and DIEA in CH2Cl2 to afford (XI), whose methyl ester is hydrolyzed in THF with LiOH in EtOH/H2O. Synthesis EN 269873: Finally intermediate (XII) is coupled with (VIII) with EDC and HOBt, and the Boc group is removed with TFA in CH2Cl2 to yield the desired product.
【1】 Patchett, A.A.; Yang, L.; Pasternak, A.; Berk, S. (Merck & Co., Inc.); Somatostatin agonists. EP 1023061; US 6057338; WO 9844921 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(rac)-(IV) | 41637 | (rac)-(1S*,3S*)-3-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid | C13H23NO4 | 详情 | 详情 | |
(rac)-(V) | 41638 | (rac)-(1S*,3R*)-3-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid | C13H23NO4 | 详情 | 详情 | |
(I) | 20406 | 3-cyanobenzoic acid | 1877-72-1 | C8H5NO2 | 详情 | 详情 |
(II) | 20407 | 3-(aminomethyl)benzoic acid | C8H9NO2 | 详情 | 详情 | |
(III) | 20408 | 3-[[(tert-butoxycarbonyl)amino]methyl]benzoic acid | C13H17NO4 | 详情 | 详情 | |
(V) | 41639 | (1S,3R)-3-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid | C13H23NO4 | 详情 | 详情 | |
(VI) | 20412 | tert-butyl [(1S,3R)-3-(hydroxymethyl)cyclohexyl]methylcarbamate | C13H25NO3 | 详情 | 详情 | |
(VII) | 20414 | tert-butyl [(1S,3R)-3-(azidomethyl)cyclohexyl]methylcarbamate | C13H24N4O2 | 详情 | 详情 | |
(VIII) | 20415 | tert-butyl [(1S,3R)-3-(aminomethyl)cyclohexyl]methylcarbamate | C13H26N2O2 | 详情 | 详情 | |
(IX) | 29274 | methyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate | C13H16N2O2 | 详情 | 详情 | |
(X) | 12138 | 1-(4-Piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 4-(2-Keto-1-benzimidazolinyl)piperidine | 20662-53-7 | C12H15N3O | 详情 | 详情 |
(XI) | 29401 | methyl (2R,3S)-3-(1H-indol-3-yl)-2-([[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino)butanoate | C26H29N5O4 | 详情 | 详情 | |
(XII) | 29402 | (2R,3S)-3-(1H-indol-3-yl)-2-([[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino)butyric acid | C25H27N5O4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(II)Treatment of (Boc)-beta-methyltryptophan (I) with SOCl2 and MeOH produced beta-methyltryptophan methyl ester (II). 3,3-Diphenylpropylamine (III) was protected with Boc2O and then alkylated with allyl bromide in the presence of potassium hexamethyldisilazide to afford (IV). Further ozonization of the allyl double bond of (IV) generated the aminoaldehyde (V). Amino ester (II) was reductively alkylated with aldehyde (V) in the presence of NaBH3CN to yield the protected diamine (VI). After acid deprotection of the Boc group of (VI), the resulting diamine (VII) was converted to imidazolinone (VIII) upon treatment with phosgene and diisopropylethylamine. Subsequent hydrolysis of the methyl ester of (VIII) gave carboxylic acid (IX).
【1】 Marino, D.; Pan, Y.; Pasternak, A.; et al.; Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett 1999, 9, 3, 491. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 28255 | (2R,3S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)butyric acid | C17H22N2O4 | 详情 | 详情 | |
(II) | 29274 | methyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate | C13H16N2O2 | 详情 | 详情 | |
(III) | 29275 | 3,3-diphenyl-1-propanamine | 5586-73-2 | C15H17N | 详情 | 详情 |
(IV) | 29276 | tert-butyl allyl(3,3-diphenylpropyl)carbamate | C23H29NO2 | 详情 | 详情 | |
(V) | 29277 | tert-butyl 3,3-diphenylpropyl(2-oxoethyl)carbamate | C22H27NO3 | 详情 | 详情 | |
(VI) | 29278 | methyl (2R,3S)-2-([2-[(tert-butoxycarbonyl)(3,3-diphenylpropyl)amino]ethyl]amino)-3-(1H-indol-3-yl)butanoate | C35H43N3O4 | 详情 | 详情 | |
(VII) | 29279 | methyl (2R,3S)-2-([2-[(3,3-diphenylpropyl)amino]ethyl]amino)-3-(1H-indol-3-yl)butanoate | C30H35N3O2 | 详情 | 详情 | |
(VIII) | 29280 | methyl (2R,3S)-2-[3-(3,3-diphenylpropyl)-2-oxo-1-imidazolidinyl]-3-(1H-indol-3-yl)butanoate | C31H33N3O3 | 详情 | 详情 | |
(IX) | 29281 | (2R,3S)-2-[3-(3,3-diphenylpropyl)-2-oxo-1-imidazolidinyl]-3-(1H-indol-3-yl)butyric acid | C30H31N3O3 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号:(VI)Condensation of beta-methyl-D-tryptophan methyl ester (VI) with disuccinimidyl carbonate (VIII) and then with 4-(2-oxo-1-benzimidazolinyl) piperidine (VII) furnished urea (IX). Basic hydrolysis of the methyl ester of (IX), followed by coupling of the resulting carboxylic acid (X) with the intermediate amine (V) in the presence of EDC and HOBt yielded the corresponding amide (XI). The Boc protecting group of (XI) was finally cleaved with trifluoroacetic acid to give the title compound.
【1】 Pasternak, A.; Chapman, K.; Guo, L.; Patchett, A.A.; Tata, J.R.; Yang, L. (Merck & Co., Inc.); Somatostatin agonists. EP 0977751; WO 9845285 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(V) | 29400 | tert-butyl [2-(aminomethyl)-4-pyridinyl]methylcarbamate | C12H19N3O2 | 详情 | 详情 | |
(VI) | 29274 | methyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate | C13H16N2O2 | 详情 | 详情 | |
(VII) | 12138 | 1-(4-Piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 4-(2-Keto-1-benzimidazolinyl)piperidine | 20662-53-7 | C12H15N3O | 详情 | 详情 |
(VIII) | 20417 | 1-([[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]oxy)-2,5-pyrrolidinedione | 74124-79-1 | C9H8N2O7 | 详情 | 详情 |
(IX) | 29401 | methyl (2R,3S)-3-(1H-indol-3-yl)-2-([[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino)butanoate | C26H29N5O4 | 详情 | 详情 | |
(X) | 29402 | (2R,3S)-3-(1H-indol-3-yl)-2-([[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino)butyric acid | C25H27N5O4 | 详情 | 详情 | |
(XI) | 29403 | tert-butyl [2-([[(2R,3S)-3-(1H-indol-3-yl)-2-([[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino)butanoyl]amino]methyl)-4-pyridinyl]methylcarbamate | C37H44N8O5 | 详情 | 详情 |