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【结 构 式】 
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【分子编号】29166 【品名】1,3-dioxolan-4-ylmethanol 【CA登记号】4740-78-7 |
【 分 子 式 】C4H8O3 【 分 子 量 】104.10572 【元素组成】C 46.15% H 7.75% O 46.11% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)The acetylation of 4-hydroxymethyl-1,3-dioxolane (XII) gives the corresponding acetate (XIII), which by reaction with acetic anhydride and ZnCl2 is converted to 1,3-diacetoxy-2-(acetoxymethoxy)propane (XIV). The condensation of (XIV) with diacetylguanine (VI) by means of ethanesulfonic acid (B) yields the triacetoxy precursor (XV), which is hydrolyzed with aqueous methylamine.
| 【1】 Field, A.K.; Tolman, R.L.; Ashton, W.A.; Karkas, J.D.; Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2'NDG). Biochem Biophys Res Commun 1982, 108, 4, 1716. |
| 【2】 Galloway, K.S.; Radatus, B.K.; Kennell, W.L.; Smith, K.O.; Ogilvie, K.K.; A new nucleoside analog, 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine, highly active in vitro aganist herpes simplex virus types 1 and 2. Antimicrob Agents Chemother 1982, 22, 1, 55-61. |
| 【3】 Pento, J.T.; Serradell, M.N.; Castaner, J.; BIOLF-62. Drugs Fut 1985, 10, 5, 365. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 19273 | acetyl chloride | 75-36-5 | C2H3ClO | 详情 | 详情 |
| (B) | 29169 | 1-ethanesulfonic acid | 594-45-6 | C2H6O3S | 详情 | 详情 |
| (VI) | 29161 | N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide; N2,9-Diacetylguanine | 3056-33-5 | C9H9N5O3 | 详情 | 详情 |
| (XII) | 29166 | 1,3-dioxolan-4-ylmethanol | 4740-78-7 | C4H8O3 | 详情 | 详情 |
| (XIII) | 29167 | 1,3-dioxolan-4-ylmethyl acetate | C6H10O4 | 详情 | 详情 | |
| (XIV) | 29168 | 3-(acetoxy)-2-[(acetoxy)methoxy]propyl acetate | C10H16O7 | 详情 | 详情 | |
| (XV) | 29170 | 2-[[2-(acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy]-3-(acetoxy)propyl acetate | C15H19N5O7 | 详情 | 详情 |
Extended Information