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【结 构 式】 
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【分子编号】29115 【品名】3-chloro-5-ethyl-N-[[(2S)-1-ethylpyrrolidinyl]methyl]-2,6-dimethoxybenzamide 【CA登记号】 |
【 分 子 式 】C18H27ClN2O3 【 分 子 量 】354.87676 【元素组成】C 60.92% H 7.67% Cl 9.99% N 7.89% O 13.53% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of 3-chloro-5-ethyl-2,6-dimethoxybenzoic acid (I) with SOCl2 gives the corresponding acyl chloride (II), which is condensed with N-ethyl-2-(aminomethyl)pyrrolidine (III) in refluxing CHCl3 yielding N-ethyl-2-(3-chloro-5-ethyl-2,6-dimethoxybenzamidomethyl)pyrrolidine (IV). Finally, this compound is treated with BBr3 in methylene chloride.
| 【1】 Florvall, G.L.; Lundstroem, J.O.G.; Raemsby, S.I.; Oegren S.O. (AstraZeneca plc); Benzamido-derivatives. DD 201886; EP 0060235; JP 57159762; US 4789683 . |
| 【2】 Serradell, M.N.; Castaner, J.; Eticlopride Hydrochloride. Drugs Fut 1985, 10, 4, 286. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29113 | 3-chloro-5-ethyl-2,6-dimethoxybenzoic acid | C11H13ClO4 | 详情 | 详情 | |
| (II) | 29114 | 3-chloro-5-ethyl-2,6-dimethoxybenzoyl chloride | C11H12Cl2O3 | 详情 | 详情 | |
| (III) | 21345 | (2S)-1-Ethyl-2-(aminomethyl)pyrrolidine; [(2S)-1-Ethylpyrrolidinyl]methanamine | C7H16N2 | 详情 | 详情 | |
| (IV) | 29115 | 3-chloro-5-ethyl-N-[[(2S)-1-ethylpyrrolidinyl]methyl]-2,6-dimethoxybenzamide | C18H27ClN2O3 | 详情 | 详情 |
Extended Information