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【结 构 式】

【分子编号】29109

【品名】2-bromo-1-(4-methoxyphenyl)-1-propanone

【CA登记号】

【 分 子 式 】C10H11BrO2

【 分 子 量 】243.10014

【元素组成】C 49.41% H 4.56% Br 32.87% O 13.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

4-Methoxyaniline (I) is reacted with 2'-bromo-4-methoxypropiophenone (II) to afford the indole (III). The ethyl group is introduced by deprotonation with sodium hydride in DMF followed by addition of ethyl bromide. The ether cleavage of (IV) with BBr3 yields the hydroxy derivative (V), which is converted to the acetate by using acetic acid an hydride in pyridine.

1 Prekajac, J.; von Angerer, E.; Benzo[a]carbazole derivatives. Synthesis, estrogen receptor binding affinities, and mammary tumor inhibiting activity. J Med Chem 1986, 29, 3, 380-6.
2 von Angerer, E.; Sheldrick, W.S.; Engel, J.; Schneider, M.R.; D-16726. Drugs Fut 1985, 10, 4, 281.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10478 p-Anisidine; 4-Methoxyaniline; 4-Methoxyphenylamine 104-94-9 C7H9NO 详情 详情
(II) 29109 2-bromo-1-(4-methoxyphenyl)-1-propanone C10H11BrO2 详情 详情
(III) 29110 4-(5-methoxy-3-methyl-1H-indol-2-yl)phenyl methyl ether C17H17NO2 详情 详情
(IV) 29111 1-ethyl-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole C19H21NO2 详情 详情
(V) 29112 1-ethyl-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol C17H17NO2 详情 详情
Extended Information