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【结 构 式】 
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【分子编号】29103 【品名】1,4,7,10-tetraoxa-13-azacyclopentadecan-13-ylphosphonic dichloride 【CA登记号】 |
【 分 子 式 】C10H20Cl2NO5P 【 分 子 量 】336.151702 【元素组成】C 35.73% H 6% Cl 21.09% N 4.17% O 23.8% P 9.21% |
合成路线1
该中间体在本合成路线中的序号：(II)Title compound can be prepared by two different ways: 1) The reaction of 1,4,7,10-tetraoxa-13-azacyclopentandecane (I) with phosphoryl chloride in the presence of triethylamine in diethyl ether gives 13-(dichlorophosphoryl)-1,4,7,10-tetraoxa-13-azacyclopentandecane (II), which is subsequently reacted with aziridine (III) in the presence of triethylamine to give azacrown-TEPA. 2) The reaction of the aziridine (III) with phosphoryl chloride in the presence of triethylamine in diethyl ether gives bis(1-aziridinyl)chlorophosphine oxide (IV), which is subsequently reacted with 1,4,7,10-tetraoxa-13-azacyclopentandecane (I) in the presence of triethylamine to afford azacrown-TEPA.
| 【1】 Okahara, M.; Nakatsuji, Y.; Maeda, H.; Facile synthesis of monoaza crown ethers. J Med Chem 1981, II, 471-472. |
| 【2】 Lukszo, J.; Sosnovsky, G.; Azacrown-TEPA. Drugs Fut 1985, 10, 4, 275. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29102 | 1,4,7,10-tetraoxa-13-azacyclopentadecane | 66943-05-3 | C10H21NO4 | 详情 | 详情 |
| (II) | 29103 | 1,4,7,10-tetraoxa-13-azacyclopentadecan-13-ylphosphonic dichloride | C10H20Cl2NO5P | 详情 | 详情 | |
| (III) | 10151 | Ethyleneimine; Aziridine; Azirane | 151-56-4 | C2H5N | 详情 | 详情 |
| (IV) | 29104 | di(1-aziridinyl)phosphinic chloride | C4H8ClN2OP | 详情 | 详情 |