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【结 构 式】

【分子编号】28969

【品名】9H-fluorene-9-carboxamide

【CA登记号】

【 分 子 式 】C14H11NO

【 分 子 量 】209.24748

【元素组成】C 80.36% H 5.3% N 6.69% O 7.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The condensation of fluorene-9-carboxamide (IV) with acrylonitrile (V) by means of benzyltrimethylammonium hydroxide (VI) in hot dioxane gives 9-carbamoyl-9-(2-cyanoethyl)fluorene (VII), which is then hydrogenated and condensed with isopropylamine (VIII) and H2 over PtO2 with the same isopropylamine (VIII) as solvent.

1 Lavagnino, E.R.; Pike, A.J.; Campbell, J.B. (Eli Lilly and Company); 9-Carbamoyl-9-(2-cyanoethyl)fluorenes. DD 158395; EP 0038676; GB 2074161; JP 1125363; US 4282170 .
2 Serradell, M.N.; Sneddon, J.; Castaner, J.; Indecainide. Drugs Fut 1985, 10, 2, 121.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IV) 28969 9H-fluorene-9-carboxamide C14H11NO 详情 详情
(V) 28970 3-butenenitrile 109-75-1 C4H5N 详情 详情
(VI) 27394 Trimethylbenzylammonium Hydroxide; N,N,N-trimethyl(phenyl)methanaminium hydroxide; Triton B; Benzyltrimethylammonium hydroxide 100-85-6 C10H17NO 详情 详情
(VII) 28971 9-(2-cyanoethyl)-9H-fluorene-9-carboxamide C17H14N2O 详情 详情
(VIII) 23933 2-Propanamine; Isopropylamine 75-31-0 C3H9N 详情 详情
Extended Information