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【结 构 式】

【分子编号】28776

【品名】methyl 2-(2-[4-[(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl]ethoxy)acetate

【CA登记号】

【 分 子 式 】C22H27ClN2O3

【 分 子 量 】402.92076

【元素组成】C 65.58% H 6.75% Cl 8.8% N 6.95% O 11.91%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of 1-(4-chlorodiphenylmethyl)piperazine (I) with methyl 2-(2-chloroethoxy)acetate (II) by means of Na2CO3 in refluxing xylene gives methyl 2-[2-[4-(4-chlorodiphenylmethyl)-1-piperazinyl]ethoxy]acetate (III), which is then hydrolyzed with KOH tn reftuxing ethanol.

1 Baltes, E.; De Lannoy, J.; Rodriguez, L. (UCB SA); Novel 2-[4-(diphenylmethyl)-1-piperazinyl]acetic acids and their amides, process for their preparation and pharmaceutical compsns. Containing them. EP 0058146; US 4525358 .
2 Castaner, J.; Serradell, M.N.; Castaner, R.M.; Cetirizine Hydrochloride. Drugs Fut 1987, 12, 7, 624.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28775 p-Chloro benzhydryl piperazine; 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine; N-(Chloro-1-benzhydryl)piperazine; 1-(4-Chlorobenzhydryl)piperazine 303-26-4 C17H19ClN2 详情 详情
(II) 16841 methyl 2-(2-chloroethoxy)acetate C5H9ClO3 详情 详情
(III) 28776 methyl 2-(2-[4-[(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl]ethoxy)acetate C22H27ClN2O3 详情 详情
Extended Information