3-chloro-N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-propanamine -Drug Synthesis Database

【结构式】

【分子编号】28715

【品名】3-chloro-N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-propanamine

【CA登记号】

【分子式】C₁₂H₁₆ClNO₂

【分子量】241.71728

【元素组成】C 59.63% H 6.67% Cl 14.67% N 5.79% O 13.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The enantiomerically pure benzodioxane derivative (VIII) was obtained in a straightforward route including five steps starting from pyrocatechin (I). Racemic (VI) was then resolved by means of crystallization with (-)-O,O'-dibenzoyl-L-tartaric acid.

参考文献中间体

合成目标

【1】 Matyus, P.; GYKI-16084. Drugs Fut 1999, 24, 10, 1072.
【2】 3(2H)-Pyridazinone derivs. and pharmaceutical compsns. containing these cpds.. WO 9638441 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	18522	3-amino-1-propanol	156-87-6	C₃H₉NO	详情	详情
(I)	11599	o-Dihydroxybenzene; Catechol; Pyrocatechol	120-80-9	C₆H₆O₂	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	28714	2,3-dihydro-1,4-benzodioxin-2-ylmethanol	3663-82-9	C₉H₁₀O₃	详情	详情
(IV)	20959	2,3-dihydro-1,4-benzodioxin-2-ylmethyl 4-methylbenzenesulfonate		C₁₆H₁₆O₅S	详情	详情
(V)	20960	3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]-1-propanol		C₁₂H₁₇NO₃	详情	详情
(VI)	28715	3-chloro-N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-propanamine		C₁₂H₁₆ClNO₂	详情	详情
(VII)	16186	(2R,3R)-2,3-bis(benzoyloxy)butanedioic acid		C₁₈H₁₄O₈	详情	详情
(VIII)	28716	3-chloro-N-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-1-propanamine		C₁₂H₁₆ClNO₂	详情	详情

Extended Information