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【结 构 式】 
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【分子编号】28616 【品名】methyl 4-hydroxy-7,8-dimethoxy-1,1-dioxo-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate 【CA登记号】 |
【 分 子 式 】C12H13NO7S 【 分 子 量 】315.30376 【元素组成】C 45.71% H 4.16% N 4.44% O 35.52% S 10.17% |
合成路线1
该中间体在本合成路线中的序号：(VII)The esterification of 3,4-dimethoxy-2-nitrobenzoic acid (I) with methyl iodide and cesium carbonate gives the corresponding methyl ester (II), which is reduced with H2 over Pd/C yielding the expected 2-amino compound (III). The reaction of (III) with NaNO2 and SO2 affords the disulfide (IV), which is cyclized with methyl glycinate (V) by means of KNO3 and SO2Cl2 giving the benzoisothiazolone derivative (VI). The rearrangement of (VI) by means of sodium methoxide yields the 1,2-benzothiazine derivative (VII), which is condensed with 3,4-methylenedioxybenzyl chloride (VIII) by means of NaH in DMF affording the N-substituted benzothiazine (IX). The reaction of (IX) with triflic anhydride gives the triflate ester (X), which is condensed with 3,4-methylenedioxythiophenol (XI) by means of NaH in DMF and hydrolyzed with LiOH in THF to provide the target compound.
| 【1】 Berryman, K.A.; Edmunds, J.J.; Bunker, A.M.; Haleen, S.; Bryant, J.; Welch, K.M.; Doherty, A.M.; Endothelin receptor antagonists: Synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides. Bioorg Med Chem 1998, 6, 9, 1447. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28611 | 3,4-dimethoxy-2-nitrobenzoic acid | C9H9NO6 | 详情 | 详情 | |
| (II) | 28612 | methyl 3,4-dimethoxy-2-nitrobenzoate | C10H11NO6 | 详情 | 详情 | |
| (III) | 28613 | methyl 2-amino-3,4-dimethoxybenzoate | C10H13NO4 | 详情 | 详情 | |
| (IV) | 28614 | methyl 2-[[2,3-dimethoxy-6-(methoxycarbonyl)phenyl]disulfanyl]-3,4-dimethoxybenzoate | C20H22O8S2 | 详情 | 详情 | |
| (V) | 17568 | methyl 2-aminoacetate | C3H7NO2 | 详情 | 详情 | |
| (VI) | 28615 | methyl 2-(6,7-dimethoxy-1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)acetate | C12H13NO7S | 详情 | 详情 | |
| (VII) | 28616 | methyl 4-hydroxy-7,8-dimethoxy-1,1-dioxo-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C12H13NO7S | 详情 | 详情 | |
| (VIII) | 28617 | 5-(chloromethyl)-1,3-benzodioxole | C8H7ClO2 | 详情 | 详情 | |
| (IX) | 28618 | methyl 2-(1,3-benzodioxol-5-ylmethyl)-4-hydroxy-7,8-dimethoxy-1,1-dioxo-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C20H19NO9S | 详情 | 详情 | |
| (X) | 28619 | methyl 2-(1,3-benzodioxol-5-ylmethyl)-7,8-dimethoxy-1,1-dioxo-4-[[(trifluoromethyl)sulfonyl]oxy]-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C21H18F3NO11S2 | 详情 | 详情 | |
| (XI) | 28620 | 1,3-benzodioxole-5-thiol | C7H6O2S | 详情 | 详情 |