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【结 构 式】

【分子编号】28565

【品名】2-biphenylenecarboxylic acid

【CA登记号】

【 分 子 式 】C13H8O2

【 分 子 量 】196.20532

【元素组成】C 79.58% H 4.11% O 16.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

Dichlorophenylpiperazine (III) was prepared from aniline (I) by dehydrative cyclization with diethanolamine (II) in the presence of P2O5 and Et3N-HCl at 200 C. Alkylation of piperazine (III) with N-(4-bromobutyl) phthalimide (IV) gave (V), and subsequent hydrazinolysis of the phthalimide provided the (4-aminobutyl)piperazine (VI). Finally, condensation of (VI) with biphenylene-2-carboxylic acid (VII) yielded the target amide.

1 Yuan, J.; Chen, X.; Brodbeck, R.; Primus, R.; Braun, J.; Wasley, W.F.; Thurkauf, A.; NGB 2904 and NGB 2849: Two highly selective dopamine D3 receptor antagonists. Bioorg Med Chem Lett 1998, 8, 19, 2715.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28562 2,3-dichlorophenylamine 608-27-5 C6H5Cl2N 详情 详情
(II) 24273 2-[(2-hydroxyethyl)amino]-1-ethanol 111-42-2 C4H11NO2 详情 详情
(III) 23943 2-methoxyisonicotinonitrile C7H6N2O 详情 详情
(IV) 17163 N-(4-Bromobutyl)phthalimide; 2-(4-Bromobutyl)-1H-isoindole-1,3(2H)-dione 5394-18-3 C12H12BrNO2 详情 详情
(V) 28563 2-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-1H-isoindole-1,3(2H)-dione C22H23Cl2N3O2 详情 详情
(VI) 28564 4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butylamine C14H21Cl2N3 详情 详情
(VII) 28565 2-biphenylenecarboxylic acid C13H8O2 详情 详情
Extended Information