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【结 构 式】 
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【分子编号】28396 【品名】(3R,4S,5R,6R,7S,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-12,13-dihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-7-[2-(phenethylimino)ethoxy]-2,10-oxacyclotetradecanedione 【CA登记号】 |
【 分 子 式 】C47H78N2O13 【 分 子 量 】879.142 【元素组成】C 64.21% H 8.94% N 3.19% O 23.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Condensation of this aldehyde (VI) with phenethyl amine (VII) produced the corresponding imine (VIII), which was finally reduced to the target amine by means of NaBH3CN or by hydrogenation over Pd/C.
| 【1】 Bui, M.H.; Plattner, J.J.; Ramney, p.M.; Nilius, A.M.; Chu, D.T.W.; Or, Y.S.; Wang, S.; Clark, R.F.; Henry, R.F.; Ma, Z.; Novel 6-O-substituted erythromycin A derivatives. Synthesis and antibacterial activity. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24 1998, San Diego) 1998, Abst F-125. |
| 【2】 Wang, S.; Ma, Z.; Clark, R.F.; et al.; Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. Bioorg Med Chem Lett 2000, 10, 8, 815. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 28393 | 2-[((3R,4S,5R,6R,7S,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-12,13-dihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecanyl)oxy]acetaldehyde | C39H69NO14 | 详情 | 详情 | |
| (VII) | 18333 | Phenethylamine; 2-Phenyl-1-ethanamine | 64-04-0 | C8H11N | 详情 | 详情 |
| (VIII) | 28396 | (3R,4S,5R,6R,7S,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-12,13-dihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-7-[2-(phenethylimino)ethoxy]-2,10-oxacyclotetradecanedione | C47H78N2O13 | 详情 | 详情 |
Extended Information