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【结 构 式】 
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【分子编号】36572 【品名】dibenzyl (2S,3R)-1-[(2S,3S)-2-([(2S,3R)-3-[[(benzyloxy)carbonyl]amino]-2-[(4-methoxybenzyl)sulfanyl]-5-[(neopentyloxy)sulfonyl]pentanoyl]amino)-3-methylpentanoyl]-2,3-pyrrolidinedicarboxylate 【CA登记号】 |
【 分 子 式 】C52H65N3O12S2 【 分 子 量 】988.23312 【元素组成】C 63.2% H 6.63% N 4.25% O 19.43% S 6.49% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)The resulting free acid (VII) was coupled with the protected dipeptide (VIII) to give tripeptide (IX). Finally, acidic removal of all protecting groups of (IX) provided the title compound.
| 【1】 Davis, C.; Bischoff, L.; Meudal, H.; et al.; Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem 1999, 42, 25, 5197. |
| 【2】 Fournie-Zaluski, M.-C.; Roques, B.; David, C.; Bischoff, L.; Llorens-Cortes, C. (CNRS (Centre National de la Recherche Scientifique); INSERM (Institut National de la Sante et de la Recherche Medicale)); Tripeptide cpds. useful as selective inhibitors of aminopeptidase A and corresponding pharmaceutical compsns.. FR 2788526; WO 0043414 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 36570 | (2S,3R)-3-[[(benzyloxy)carbonyl]amino]-2-[(4-methoxybenzyl)sulfanyl]-5-[(neopentyloxy)sulfonyl]pentanoic acid | C26H35NO8S2 | 详情 | 详情 | |
| (VIII) | 36571 | dibenzyl (2S,3R)-1-[(2S,3S)-2-amino-3-methylpentanoyl]-2,3-pyrrolidinedicarboxylate | C26H32N2O5 | 详情 | 详情 | |
| (IX) | 36572 | dibenzyl (2S,3R)-1-[(2S,3S)-2-([(2S,3R)-3-[[(benzyloxy)carbonyl]amino]-2-[(4-methoxybenzyl)sulfanyl]-5-[(neopentyloxy)sulfonyl]pentanoyl]amino)-3-methylpentanoyl]-2,3-pyrrolidinedicarboxylate | C52H65N3O12S2 | 详情 | 详情 |
Extended Information