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【结 构 式】 
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【分子编号】30163 【品名】allyl (4S,5R,6S)-6-((1R)-1-[[(allyloxy)carbonyl]oxy]ethyl)-3-[[1,1-dioxo-6-[2-[(triethylsilyl)oxy]ethyl]-2H-naphtho[1,8-cd]isothiazol-2(1H)-yl]methyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 【CA登记号】 |
【 分 子 式 】C36H46N2O9SSi 【 分 子 量 】710.92082 【元素组成】C 60.82% H 6.52% N 3.94% O 20.25% S 4.51% Si 3.95% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LII)Condensation of azetidinone (XXIX) with sultam (VIIIb) to afford (LI), which was cyclized to the corresponding carbapenem (LII) upon refluxing in toluene. The title compound was then prepared by a sequence analogous to Scheme 25884901g.
| 【1】 Wilkening, R.R.; Wildonger, K.J.; Ratcliffe, R.W.; et al.; Synthesis and evaluation of anti-MRSA 1beta-methyl-2-(naphthosultamyl) methyl-carbapenems: Discovery of L-786,392. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24 1998, San Diego) 1998, Abst F-32. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIIIb) | 30125 | 6-[2-[(triethylsilyl)oxy]ethyl]-2H-naphtho[1,8-cd]isothiazole-1,1(2H)-dione | C18H25NO3SSi | 详情 | 详情 | |
| (XXIX) | 30144 | allyl 2-[(2R,3S)-3-((1R)-1-[[(allyloxy)carbonyl]oxy]ethyl)-2-[(1R)-3-hydroxy-1-methyl-2-oxopropyl]-4-oxoazetidinyl]-2-(triphenylphosphoranylidene)acetate | C36H38NO8P | 详情 | 详情 | |
| (LI) | 30162 | allyl 2-((2R,3S)-3-((1R)-1-[[(allyloxy)carbonyl]oxy]ethyl)-2-[(1R)-3-[1,1-dioxo-6-[2-[(triethylsilyl)oxy]ethyl]-2H-naphtho[1,8-cd]isothiazol-2(1H)-yl]-1-methyl-2-oxopropyl]-4-oxoazetidinyl)-2-(triphenylphosphoranylidene)acetate | C54H61N2O10PSSi | 详情 | 详情 | |
| (LII) | 30163 | allyl (4S,5R,6S)-6-((1R)-1-[[(allyloxy)carbonyl]oxy]ethyl)-3-[[1,1-dioxo-6-[2-[(triethylsilyl)oxy]ethyl]-2H-naphtho[1,8-cd]isothiazol-2(1H)-yl]methyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C36H46N2O9SSi | 详情 | 详情 |
Extended Information