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【结 构 式】

【分子编号】29786

【品名】2-(3-methyl-4-oxo-1,3-thiazolidin-2-ylidene)acetic acid

【CA登记号】

【 分 子 式 】C6H7NO3S

【 分 子 量 】173.19252

【元素组成】C 41.61% H 4.07% N 8.09% O 27.71% S 18.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Reaction of tert-butyl cyanoacetate (I) with ethyl mercaptoacetate (II) in the presence of potassium carbonate, followed by N-methylation and ester cleavage affords the intermediate carboxylic acid (III). This compound, by POCl3 in dimethylformamide or by Br2/TPP, is converted to the corresponding acid halogenide (IV), which is finally condensed with 2-chloro-6-methylaniline (V).

1 Bartoszyk, G.; Hartenstein, J.; Herrmann, M.; Fritschi, E.; Satzinger, G. (Godecke AG); 4-Oxothiazolidin-2-ylideneacetamide derivatives as CNS agents. DE 3317000; EP 0124911; US 4563471 .
2 Satzinger, G.; Ralitoline. Drugs Fut 1985, 10, 11, 920.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IVa) 29787 2-(3-methyl-4-oxo-1,3-thiazolidin-2-ylidene)acetyl chloride C6H6ClNO2S 详情 详情
(IVb) 29788 2-(3-methyl-4-oxo-1,3-thiazolidin-2-ylidene)acetyl bromide C6H6BrNO2S 详情 详情
(I) 14330 tert-Butyl cyanoacetate; tert-butyl 2-cyanoacetate 1116-98-9 C7H11NO2 详情 详情
(II) 23995 ethyl 2-sulfanylacetate 2713-34-0 C4H8O2S 详情 详情
(III) 29786 2-(3-methyl-4-oxo-1,3-thiazolidin-2-ylidene)acetic acid C6H7NO3S 详情 详情
(V) 29789 2-chloro-6-methylphenylamine; 2-chloro-6-methylaniline 87-63-8 C7H8ClN 详情 详情
Extended Information