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【结 构 式】 
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【分子编号】35494 【品名】(1,4-dibenzyl-2-piperazinyl)methyl phenyl carbonate 【CA登记号】 |
【 分 子 式 】C26H28N2O3 【 分 子 量 】416.52 【元素组成】C 74.98% H 6.78% N 6.73% O 11.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The esterification of 1,4-dibenzyl-2-(hydroxymethyl)piperazine (I) with diphenyl carbonate and triethylamine in dichloromethane gives the mixed carbonate ester (II), which is treated with refluxing diethylamine to yield the carbamate ester (III). The deprotection of (III) with H2 over Pd/C in ethanol/HCl affords N,N-diethylcarbamic acid piperazin-2-ylmethyl ester (IV), which is finally condensed with 3,4,5-trimethoxybenzoyl chloride (V) by means of triethylamine in dichloromethane.
| 【1】 Martin, M.; Clayette, P.; Godfroid, J.-J.; Heymans, F.; Lamouri, A.; Dereuddre-Bosquet, N. (Commissariat a l'Energie Atomique; Université Denis Diderot - Paris 7); Piperazine derivs. inhibiting human immunodeficiency virus replication. FR 2780649; WO 0001677 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35493 | (1,4-dibenzyl-2-piperazinyl)methanol | C19H24N2O | 详情 | 详情 | |
| (II) | 35494 | (1,4-dibenzyl-2-piperazinyl)methyl phenyl carbonate | C26H28N2O3 | 详情 | 详情 | |
| (III) | 35495 | (1,4-dibenzyl-2-piperazinyl)methyl diethylcarbamate | C24H33N3O2 | 详情 | 详情 | |
| (IV) | 35496 | 2-piperazinylmethyl diethylcarbamate | C10H21N3O2 | 详情 | 详情 | |
| (V) | 13571 | 3,4,5Ttrimethoxybenzoyl chloride | 4521-61-3 | C10H11ClO4 | 详情 | 详情 |
Extended Information